10167-23-4

Basic information

• Product Name: o-Nitrobenzoylglycine
• Synonyms: N-(2-Nitrobenzoyl)glycine;o-Nitrobenzoylglycine;2-(2-NitrobenzaMido)acetic acid;Glycine, N-(2-nitrobenzoyl)-;2-[(2-nitrobenzoyl)amino]acetic acid;2-[(2-nitrophenyl)carbonylamino]ethanoic acid;2-[[(2-nitrophenyl)-oxomethyl]amino]acetic acid;Oprea1_397730
• CAS NO: 10167-23-4
• Molecular Formula: C₉H₈N₂O₅
• Molecular Weight: 224.17022
• Mol File: 10167-23-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 190℃
• Appearance: /
• Density: 1.467
• Storage Temp.: 2-8°C
• CAS DataBase Reference: o-Nitrobenzoylglycine(CAS DataBase Reference)
• NIST Chemistry Reference: o-Nitrobenzoylglycine(10167-23-4)
• EPA Substance Registry System: o-Nitrobenzoylglycine(10167-23-4)

Safety Data

• Hazardous Substances Data: 10167-23-4(Hazardous Substances Data)

Usage

General Description

o-Nitrobenzoylglycine, also known as N-(2-Nitrobenzoyl)glycine, is a chemical compound that belongs to the class of nitrobenzoyl compounds. It is a derivative of benzoyl glycine and has a nitro group attached to the ortho position of the benzoyl ring. o-Nitrobenzoylglycine is often used in the synthesis of various organic compounds and pharmaceuticals. It has been studied for its potential biological activities and has shown to possess anti-inflammatory and antifungal properties. o-Nitrobenzoylglycine is also used as a key intermediate in organic synthesis and can be found in research laboratories and chemical industries. Overall, it is a versatile chemical with various applications in both synthetic chemistry and pharmacology.

Upstream product

• 5177-49-1 ethyl 2-(2-nitrobenzamido)acetate 
• 56-40-6 glycine 
• 610-14-0 2-nitrobenzyl chloride 
• 552-16-9 ortho-nitrobenzoic acid 
• 623-33-6 glycine ethyl ester hydrochloride 

Downstream Products

• 25673-44-3 4-(Z)-benzylidene-2-(2-nitro-phenyl)-4H-oxazol-5-one 
• 4211-97-6 2-(2-nitro-phenyl)-4-thiophen-2-ylmethylene-4H-oxazol-5-one 
• 20063-40-5 3,3'-{3-methyl-4-[2-(2-nitro-phenyl)-5-oxo-oxazol-4-ylidenemethyl]-phenylazanediyl}-bis-propionitrile 
• 1224962-90-6 C₁₁H₁₀N₂O₆ 
• 313970-63-7 4-(4-nitrobenzylidene)-2-(2-nitrophenyl)-5(4H)-oxazolone 
• 313264-40-3 4-(4-methoxybenzylidene)-2-(2-nitrophenyl)-5(4H)-oxazolone 

Relevant articles and documents

Synthesis and Quantitative Structure-activity Relationships Study for Arylpropenamide Derivatives as Inhibitors of Hepatitis B Virus Replication

A series of new arylpropenamide derivatives containing different aryl groups were synthesized, characterized, and evaluated for their anti-hepatitis B virus (HBV) activities. A new high accuracy QSAR model of arylpropenamide was constructed based on a more completely activities data and calculation parameter. The 2D-QSAR equations, by using DFT and multiple linear regression analysis methods, revealed that higher value of thermal energy (TE) and lower entropy (S?) increase the anti-HBV activities of the arylpropenamide molecules. Predictive 3D-QSAR models were established by SYBYL multifit molecular alignment rule. The optimum models were all statistically significant with cross-validated and conventional coefficients, indicating that they were reliable enough for activity prediction.

Synthesis and in Vitro Aldolase Reductase Inhibitory Activity of Compounds Containing an N-Acylglycine Moiety

A number of N-benzoylglycines (6), N-acetyl-N-phenylglycines (7), N-benzoyl-N-phenylglycines (8), and tricyclic N-acetic acids (9-12) were synthesized as analogues of the N-acylglycine-containing aldolase reductase inhibitors alrestatin and 2-oxoquinoline-1-acetic acid.Derivatives of 6, which represent ring-simplified analogues of alrestatin, are very weak inhibitors of aldolase reductase obtained from rat lens, producing 50percent inhibition only at concentrations exceeding 100 μM.Compounds of series 7 were designed as ring-opened analogues of the 2-oxoquinolines.While this derivatives are more potent than compounds of series 6 (IC 50s of 6-80 μM), they are less active than the corresponding 2-oxoquinolines.Analogues of series 8 were designed as hybrid structures of both alrestatin and the 2-oxoquinoline-1-acetic acids.These compounds are substantially more potent than compounds of series 6 and 7 and display inhibitory activities comparable to or greater than alrestatin or the 2-oxoquinolines (IC 50s of 0.1-10 μM).Of the rigid analogues of 8, the most potent derivative is benzoxindol (12) with an IC 50 of 0.67 μM, suggesting that fusion of the two aromatic rings of 8 in a coplanar conformation may optimize affinity for aldose reductase in this series.