101796-28-5Relevant articles and documents
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Fox et al.
, p. 2775,2777 (1957)
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Anti-flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues
McGuigan, Christopher,Serpi, Michaela,Slusarczyk, Magdalena,Ferrari, Valentina,Pertusati, Fabrizio,Meneghesso, Silvia,Derudas, Marco,Farleigh, Laura,Zanetta, Paola,Bugert, Joachim
, p. 227 - 235 (2016/07/07)
A series of tritylated and dimethoxytritylated analogues of selected pyrimidine and purine nucleosides were synthesized and evaluated for their in vitro inhibitory activity against two important members of the genus Flavivirus in the Flaviviridae family, the yellow fever (YFV) and dengue viruses (DENV). Among all compounds tested, the 5′-O-tritylated and the 5′-O-dimethoxytritylated 5-fluorouridine derivatives exerted potency against YFV. Interestingly in the series of purine analogues, the 5′O, N-bis-tritylated fludarabine derivative revealed strong inhibitory activity against DENV at μm concentrations, however significantly weaker potency against YFV.
Synthesis and anti-HIV activity of 4′-cyano-2′,3′ -didehydro-3′-deoxythymidine
Haraguchi, Kazuhiro,Itoh, Yoshiharu,Takeda, Shingo,Honma, Yosuke,Tanaka, Hiromichi,Nitanda, Takao,Baba, Masanori,Dutschman, Ginger E.,Cheng, Yung-Chi
, p. 647 - 654 (2007/10/03)
A new anti-HIV agent 4′-cyano-2′,3′-didehydro-3′ -deoxythymidine (9) was synthesized by allylic substitution of the 3′,4′-unsaturated nucleoside 14, having a leaving group at the 2′-position, with cyanotrimethylsilane in the presence of SnCl4. Evaluation
