102-02-3 Usage
Description
PHENYLBIGUANIDE, also known as 1-Phenylbiguanide, is a member of the class of biguanides. It is a biguanide in which one of the terminal nitrogen atoms is substituted by a phenyl group. PHENYLBIGUANIDE acts as a 5-hydroxytryptamine receptor agonist and is known to increase extracellular dopamine release in rat nucleus accumbens in vivo. It is also used as a building block for the synthesis of heterocyclic compounds.
Uses
Used in Pharmaceutical Industry:
PHENYLBIGUANIDE is used as a 5-hydroxytryptamine receptor agonist for its ability to increase extracellular dopamine release in rat nucleus accumbens in vivo. This makes it a potential candidate for the development of treatments related to dopamine-related disorders.
Used in Chemical Synthesis:
PHENYLBIGUANIDE is used as a building block for the synthesis of heterocyclic compounds, which are important in various chemical and pharmaceutical applications. Its unique structure allows for the creation of a wide range of complex molecules with diverse properties and functions.
Purification Methods
Crystallise the biguanide from water or toluene. [Beilstein 12 H 370, 12 I 236, 12 III 807.]
Check Digit Verification of cas no
The CAS Registry Mumber 102-02-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 2 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 102-02:
(5*1)+(4*0)+(3*2)+(2*0)+(1*2)=13
13 % 10 = 3
So 102-02-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H11N5/c9-7(10)13-8(11)12-6-4-2-1-3-5-6/h1-5H,(H6,9,10,11,12,13)
102-02-3Relevant articles and documents
-
Schaefer,Bojanowski
, p. 364,365 (1972)
-
NOVEL CYCLIC GMP-AMP SYNTHASE (CGAS) INHIBITORS AND THEIR METHOD OF USE
-
Page/Page column 60; 69, (2020/01/08)
Methods of treating diseases related to cGAS activation. Small molecule inhibitors of cGAS and pharmaceutical compositions and uses thereof in treating autoimmune diseases or inflammation.
Novel compounds having treatment of immune diseases and use therof
-
Paragraph 0086-0092, (2016/11/24)
The present invention relates to a novel compound capable of effectively treating and preventing immune disease and to a use thereof. The novel compound of the present invention suppresses the production of inflammatory cytokines and increases activities of regulatory T cells having immune regulatory ability. In addition, the compound of the present invention controls over an excessive immune response by inhibiting the production of autoantibodies and differentiation of osteoclasts, thereby being able to be used for treating immune diseases induced by regulatory anomalies of various immune response such as autoimmune disease, inflammatory diseases, and transplant rejection.(a) Cell toxicity effect control(MTT assay)(AA) Normal mouse cell(b) Autoantibody production immune reaction control(c) Inflammatory cytokine production control(d) Inflammatory gene expression controlCOPYRIGHT KIPO 2016