1025080-35-6

Basic information

• Product Name: 1-cyclopropyl-6-fluoro-3-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]-7-piperazino-1,4-dihydro-4-quinolinone
• CAS NO: 1025080-35-6
• Molecular Weight: 476.467
• Mol File: 1025080-35-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-cyclopropyl-6-fluoro-3-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]-7-piperazino-1,4-dihydro-4-quinolinone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclopropyl-6-fluoro-3-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]-7-piperazino-1,4-dihydro-4-quinolinone(1025080-35-6)
• EPA Substance Registry System: 1-cyclopropyl-6-fluoro-3-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]-7-piperazino-1,4-dihydro-4-quinolinone(1025080-35-6)

Safety Data

• Hazardous Substances Data: 1025080-35-6(Hazardous Substances Data)

Upstream product

• 85721-33-1 ciprofloxacin 
• 636-97-5 N-amino-(4-nitrophenyl)carboxamide 

Relevant articles and documents

Synthesis and antiproliferative activity of 1-[(sub)]-6-fluoro-3-[(sub)]-1, 3,4-oxadiazol-2-yl-7-piperazino-1, 4-dihydro-4-quinolinone derivatives

A series of 1-[(sub)]-6-fluoro-3- [(sub)]-1, 3, 4-oxadiazol-2-yl-7- piperazino-1, 4-dihydro 4-quinolinones were synthesized by the reaction between ciprofloxacin and norfloxacin with an appropriate acid hydrazide in phosphorous oxychloride. All newly synthesized compounds were evaluated for their antiproliferative activities against human lung tumor cell lines (A 549). Fluoroquinolone with oxadiazole (Q 2 ) 1-cyclopropyl-6-fluoro-3- [5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]-7-piperazino-1, 4-dihydro-4-quinolinone was found to be the most active compound in vitro with a half-maximal inhibitory concentration (IC50) of 9.0 μg/mL.