10264-30-9

Basic information

• Product Name: Benzeneacetamide, N-hexyl-
• CAS NO: 10264-30-9
• Molecular Formula: C14H21NO
• Molecular Weight: 219.327
• Mol File: 10264-30-9.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Benzeneacetamide, N-hexyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetamide, N-hexyl-(10264-30-9)
• EPA Substance Registry System: Benzeneacetamide, N-hexyl-(10264-30-9)

Safety Data

• Hazardous Substances Data: 10264-30-9(Hazardous Substances Data)

Upstream product

• 111-26-2 hexan-1-amine 
• 536-74-3 phenylacetylene 
• 6926-45-0 1-azidohexane 
• 122-78-1 phenylacetaldehyde 
• 103-82-2 phenylacetic acid 
• 628-73-9 hexanenitrile 
• 60-12-8 2-phenylethanol 
• 102-04-5 1,3-Diphenylpropanone 
• 55628-82-5 1-(Phenylacetyl)imidazole 
• 2763-88-4 N,N'-di-n-hexylurea 

Relevant articles and documents

Direct amide synthesis from alcohols and amines by phosphine-free ruthenium catalyst systems

Amides are synthesized directly from alcohols and amines in high yields using an in situ generated catalyst from easily available ruthenium complexes such as the (p-cymene)ruthenium dichloride dimer, [Ru(p-cymeme)Cl 2]2, or the (benz

Direct amide synthesis from either alcohols or aldehydes with amines: Activity of Ru(II) hydride and Ru(0) complexes

An in situ generated catalyst from readily available RuH 2(PPh3)4, an N-heterocyclic carbene (NHC) precursor, NaH, and acetonitrile was developed. The catalyst showed high activity for the amide synthesis directly from either alcohols or aldehydes with amines. When a mixture of an alcohol and an aldehyde was reacted with an amine, both of the corresponding amides were obtained with good yields. Homogeneous Ru(0) complexes such as (4-1,5-cyclooctadiene)(6-1,3,5- cyclooctatriene)ruthenium [Ru(cod)(cot)] and Ru3(CO)12 were also active in the amidation of an alcohol or an aldehyde with the help of an in situ generated NHC ligand.

N-Heterocyclic carbene-based well-defined ruthenium hydride complexes for direct amide synthesis from alcohols and amines under base-free conditions

Readily synthesized, well-defined N-heterocyclic carbene-based ruthenium(II) hydride complexes were developed for amide synthesis from alcohols and amines under base-free conditions. Diverse amides were synthesized in fair-to-excellent yields. In the case of secondary amines, where direct dehydrogenative amidation is not feasible, a catalytic amount of a base was required to promote the transamidation of esters, which are byproducts of alcohol dimerization.

Dehydrogenative amide synthesis: Azide as a nitrogen source

A new atom-economical strategy to amide linkage from an azide and alcohol liberating hydrogen and nitrogen was developed with an in situ generated ruthenium catalytic system. The reaction has broad substrate generality including diols for the synthesis of cyclic imides.