10272-49-8

Basic information

• Product Name: 4-PHENYLPIPERIDINE HYDROCHLORIDE
• Synonyms: 4-PHENYLPIPERIDINE HYDROCHLORIDE;4-phenylpiperidinium chloride;4-Phenylpiperdine HCL;4-Phenylpiperdine hydrochloride;1,2,3,6-Tetrahydro-4-phenylpiperidine hydrochloride
• CAS NO: 10272-49-8
• Molecular Formula: C₁₁H₁₅N*ClH
• Molecular Weight: 197.7
• EINECS: 233-617-0
• Mol File: 10272-49-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 164-165℃
• Boiling Point: 259.9°Cat760mmHg
• Flash Point: 113°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.0126mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-PHENYLPIPERIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENYLPIPERIDINE HYDROCHLORIDE(10272-49-8)
• EPA Substance Registry System: 4-PHENYLPIPERIDINE HYDROCHLORIDE(10272-49-8)

Safety Data

• Hazardous Substances Data: 10272-49-8(Hazardous Substances Data)

Usage

Chemical Properties

mp 154-158°C

InChI:InChI=1/C11H15N.ClH/c1-2-4-10(5-3-1)11-6-8-12-9-7-11;/h1-5,11-12H,6-9H2;1H

Upstream product

• 771-99-3 4-phenylpiperidine 
• 100-58-3 phenylmagnesium bromide 
• 63843-83-4 1-benzyl-4-hydroxy-4-phenylpiperidine 
• 38025-45-5 1-benzyl-4-phenyl-1,2,3,6-tetrahydro-pyridine 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 108-86-1 bromobenzene 
• 43064-12-6 1,2,3,6-tetrahydro-4-phenylpyridine hydrochloride 
• 94163-98-1 1-benzyl-4-phenyl-1,2,5,6-tetrahydropirydine hydrochloride 

Downstream Products

• 110469-35-7 1-[6-Hydroxy-4-methoxy-7-(4-phenyl-piperidin-1-ylmethyl)-benzofuran-5-yl]-ethanone 
• 478178-91-5 2-methyl-5-nitro-6-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-3H-pyrimidin-4-one 
• 157133-89-6 2,2,2-trifluoro-1-(4-phenyl-1-piperidinyl)-1-ethanone 
• 521070-59-7 4-phenyl-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]-1-piperidinecarboxamide 
• 1400928-46-2 C₂₅H₃₁N₃O₂ 
• 1401997-72-5 2-(2,6-dihexyl-4-phenylpiperidin-1-yl)pyridine 
• 1026504-57-3 2-(4-phenylpiperidin-1-yl)pyridine 
• 697304-21-5 ethyl (2R,3S)-3-(1H-indol-3-yl)-2-{[(4-phenylpiperidin-1-yl)carbonyl]amino}butanoate 
• 437995-23-8 5-chloro-2-[3-(4-phenyl-1-piperidyl)propyl]-4(3H)-quinazolinone 
• 400770-04-9 methyl 3-((4-phenyl)piperidin-1-yl)-1-isopropylcyclopentane carboxylate 

Relevant articles and documents

Synthetic method of 4 -phenyl piperidine hydrochloride

The invention discloses a synthesis method of 4 -phenylpiperidine hydrochloride, and the route is as shown in the specification. The method has the advantages of cheap and easily available raw materials, simple operation and post-treatment, high yield, high product purity and the like, and is suitable for industrial production.

Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6- tetrahydropyridines as 5-HT2C agonists

A series of substituted 4-arylpiperidines and a smaller family of 4-aryl-1,2,3,6-tetrahydropyridines were synthesized and their biological activity at the 5-HT2C receptor studied to determine whether either series showed noteworthy agonist activity. Structure-activity relationships were developed from the performed receptor binding assays and functional studies, and the results of the analysis are presented herein.

Phenoxyalkylamine derivatives useful as opioid receptor agonists

A medicament useful for preventive and/or therapeutic treatment of nerve system diseases which comprises, as an active ingredient, a compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof: wherein, X represents a group represented by the following general formula (II), (III), (IV), (V), or (VI), “A” represents a saturated or unsaturated 3- to 6-membered carbocyclic group and the like, “B” represents CH2 and the like, “n” represents 0 to 2, R1 represents a hydrogen atom, a halogen atom and the like, R2, R3, and R7 to R14 represent a hydrogen atom, a lower alkyl group which may be substituted and the like, R4 represents a hydrogen atom, a lower alkyl group which may be substituted and the like, R5 represents a hydrogen atom, a halogen atom and the like, R6 represents a saturated or unsaturated monocyclic or bicyclic carbocyclic group and the like, and R5 and R6, R7 and R8, R9 and R10, or R11 and R12 may bind to each other to form a cyclic structure.