1028486-06-7Relevant articles and documents
MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors
Sells, Todd B.,Chau, Ryan,Ecsedy, Jeffrey A.,Gershman, Rachel E.,Hoar, Kara,Huck, Jessica,Janowick, David A.,Kadambi, Vivek J.,Leroy, Patrick J.,Stirling, Matthew,Stroud, Stephen G.,Vos, Tricia J.,Weatherhead, Gabriel S.,Wysong, Deborah R.,Zhang, Mengkun,Balani, Suresh K.,Bolen, Joseph B.,Manfredi, Mark G.,Claiborne, Christopher F.
, p. 630 - 634 (2015/06/30)
The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, selective,
COMPOUNDS FOR INHIBITING MITOTIC PROGRESSION
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Page/Page column 30, (2008/12/05)
The present invention relates to compounds of formula (I) : and methods for the treatment of cancer. In particular, the invention provides potent inhibitors of Aurora A kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.