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1028486-06-7

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1028486-06-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1028486-06-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,8,4,8 and 6 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1028486-06:
(9*1)+(8*0)+(7*2)+(6*8)+(5*4)+(4*8)+(3*6)+(2*0)+(1*6)=147
147 % 10 = 7
So 1028486-06-7 is a valid CAS Registry Number.

1028486-06-7Downstream Products

1028486-06-7Relevant articles and documents

MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors

Sells, Todd B.,Chau, Ryan,Ecsedy, Jeffrey A.,Gershman, Rachel E.,Hoar, Kara,Huck, Jessica,Janowick, David A.,Kadambi, Vivek J.,Leroy, Patrick J.,Stirling, Matthew,Stroud, Stephen G.,Vos, Tricia J.,Weatherhead, Gabriel S.,Wysong, Deborah R.,Zhang, Mengkun,Balani, Suresh K.,Bolen, Joseph B.,Manfredi, Mark G.,Claiborne, Christopher F.

, p. 630 - 634 (2015/06/30)

The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, selective,

COMPOUNDS FOR INHIBITING MITOTIC PROGRESSION

-

Page/Page column 30, (2008/12/05)

The present invention relates to compounds of formula (I) : and methods for the treatment of cancer. In particular, the invention provides potent inhibitors of Aurora A kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.

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