10286-86-9

Basic information

• Product Name: Benzamide, N-(2-chloro-6-methylphenyl)-
• CAS NO: 10286-86-9
• Molecular Formula: C14H12ClNO
• Molecular Weight: 245.708
• Mol File: 10286-86-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzamide, N-(2-chloro-6-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-(2-chloro-6-methylphenyl)-(10286-86-9)
• EPA Substance Registry System: Benzamide, N-(2-chloro-6-methylphenyl)-(10286-86-9)

Safety Data

• Hazardous Substances Data: 10286-86-9(Hazardous Substances Data)

Upstream product

• 118923-96-9 2-chloro-6-methylphenyl isocyanide 
• 108-88-3 toluene 
• 611-22-3 N-(o-tolyl)hydroxylamine 
• 98-88-4 benzoyl chloride 
• 87-63-8 2-chloro-6-methylaniline 
• 1143-74-4 N-o-tolylbenzohydroxamic acid 
• 88-72-2 1-methyl-2-nitrobenzene 

Downstream Products

• 52159-88-3 1-benzyl-4-methyl-2-phenyl-1H-benzo[d]imidazole 
• 1402938-82-2 (Z)-N-(2-chloro-6-methylphenyl)benzimidoyl chloride 
• 77791-11-8 4-methyl-2-phenyl-1,3-benzoxazole 
• 1025807-12-8 4-(7-chloro-2-phenyl-1H-indol-3-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester 
• 66866-01-1 7-chloro-2-phenyl-1H-indole 

Relevant articles and documents

Exploiting the Reactivity of Isocyanide: Coupling Reaction between Isocyanide and Toluene Derivatives Using the Isocyano Group as an N1 Synthon

An unusual oxidative coupling reaction of isocyanide and toluene derivatives using tetrabutylammonium iodide (TBAI) as a catalyst is disclosed. The experimental results and mechanistic study show that the isocyano group acts formally as an N1 synthon during the transformation, thus expanding the reactivity profile of isocyanide.

Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis

Novel N,N-disubstituted indol-3-ylglyoxylamides (1-56), bearing different combinations of substituents R1-R5, were synthesized and evaluated as ligands of the translocator protein (TSPO), the 18 kDa protein representing the minimal f

3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT2A receptor antagonists

The development of very high affinity, selective, and bioavailable h5-HT2A receptor antagonists is described. By investigation of the optimal position for the basic nitrogen in a series of 2-phenyl-3-piperidylindoles, it was found that with the basic nitrogen at the 3-position of the piperidine it was not necessary to further substitute the piperidine in order to obtain good binding at h5-HT2A receptors. This meant the compounds no longer had high affinity at the IKr potassium channel, an issue with previous series of 2-aryl-3-(4-piperidyl)indoles. Improvements could be made to oral bioavailability in this series by reduction of the pKa of the basic nitrogen, by adding a fluorine atom to the piperidine ring, leading to 3-(4-fluoropiperidin-3-yl)-2-phenyl-1H-indole (17). Metabolic studies with this compound identified oxidation at the 6-position of the indole as a major route in vitro and in vivo in rats. Blocking this position with a fluorine atom led to 6-fluoro-3-(4-fluoropiperidin-3-yl)-2-phenyl-1H-indole (22), an antagonist with 0.06 nM affinity for h5-HT2A receptors, with bioavailability of 80% and half-life of 12 h in rats.