1029654-30-5

Basic information

• Product Name: (2-FLUORO-4-METHYLPYRIDIN-3-YL)BORONIC ACID
• Synonyms: 2-FLUORO-4-PICOLINE-3-BORONIC ACID;(2-FLUORO-4-METHYLPYRIDIN-3-YL)BORONIC ACID;2-FLUORO-4-METHYLPYRIDINE-3-BORONIC ACID
• CAS NO: 1029654-30-5
• Molecular Formula: C6H7BFNO2
• Molecular Weight: 154.93
• Product Categories: Boronic Acid
• Mol File: 1029654-30-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 341.5±52.0 °C(Predicted)
• Appearance: /
• Density: 1.28±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 6.75±0.58(Predicted)
• CAS DataBase Reference: (2-FLUORO-4-METHYLPYRIDIN-3-YL)BORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2-FLUORO-4-METHYLPYRIDIN-3-YL)BORONIC ACID(1029654-30-5)
• EPA Substance Registry System: (2-FLUORO-4-METHYLPYRIDIN-3-YL)BORONIC ACID(1029654-30-5)

Safety Data

• Hazardous Substances Data: 1029654-30-5(Hazardous Substances Data)

Usage

General Description

(2-Fluoro-4-methylpyridin-3-yl)boronic acid is an organic compound with boronic acid and fluoropyridine functional groups. The boronic acid group is known for its ability to form covalent bonds with various substrates and is frequently utilized in the field of medicinal chemistry and drug development. The molecule has a methyl group attached to its pyridine ring, and a fluorine atom, which is often used in organic chemistry to modify reactivity and electronic properties. Therefore, it can be used as a building block in the synthesis of various other complex molecules. Like all boronic acids, it has the potential to form reversible covalent complexes with sugars, amino acids, and other biological molecules.

Upstream product

• 884495-46-9 2-fluoro-3-bromo-4-methylpyridine 

Relevant articles and documents

Preparation method of 2-fluoro-4-methyl-3-pyridinylboronic acid

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method of 2-fluoro-4-methyl-3-pyridinylboronic acid. The preparation method comprises the following steps: performing a lithium-halogen exchange reaction and a boronizing reaction on 2-fluoro-3-bromo-4-methylpyridine serving as a raw material, a lithiation agent and a boronizing agent at alow temperature through a one-pot method to obtain 2-fluoro-4-methyl-3-pyridine ester borate; dehydrating the prepared 2-fluoro-4-methyl-3-pyridine ester borate with a 10 percent by mass sodium hydroxide aqueous solution to obtain a 2-fluoro-4-methyl-3-pyridinylboronic acid crude product; purifying the 2-fluoro-4-methyl-3-pyridinylboronic acid crude product to obtain a 2-fluoro-4-methyl-3-pyridinylboronic acid pure product. In the reaction, tetrahydrofuran is taken as a reaction solvent. The preparation method of the 2-fluoro-4-methyl-3-pyridinylboronic acid has the advantages of low cost, adoption of readily-available raw materials, mild reaction conditions, simple post-treatment operation, lower production cost, high yield, lower reaction cost, and suitability for industrial production.