1032903-62-0

Basic information

• Product Name: 4-(5-isopropoxy-2-Methyl-4-nitrophenyl)pyridine
• Synonyms: 4-(5-isopropoxy-2-Methyl-4-nitrophenyl)pyridine;EOS-60653;4-(2-methyl-4-nitro-5-propan-2-yloxyphenyl)pyridine
• CAS NO: 1032903-62-0
• Molecular Formula: C₁₅H₁₆N₂O₃
• Molecular Weight: 272.29914
• Mol File: 1032903-62-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 404.2±40.0 °C(Predicted)
• Appearance: /
• Density: 1.166±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.61±0.10(Predicted)
• CAS DataBase Reference: 4-(5-isopropoxy-2-Methyl-4-nitrophenyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-isopropoxy-2-Methyl-4-nitrophenyl)pyridine(1032903-62-0)
• EPA Substance Registry System: 4-(5-isopropoxy-2-Methyl-4-nitrophenyl)pyridine(1032903-62-0)

Safety Data

• Hazardous Substances Data: 1032903-62-0(Hazardous Substances Data)

Usage

General Description

4-(5-isopropoxy-2-methyl-4-nitrophenyl)pyridine is a complex organic compound comprising of various functional groups. Notable components of its chemical structure include a pyridine ring, a nitrophenyl group, and an isopropoxy group. The pyridine ring is a simple aromatic ring with one nitrogen atom, while the nitrophenyl group, is characterized by a nitro (NO2) group attached to a phenyl ring. Alongside, an isopropoxy group, an alkyl ether, is also present in this compound. It contains an isopropyl group bonded to an oxygen atom. The exact properties such as melting point, boiling point, density, among others would depend on its precise molecular configuration, purity, and conditions. It's use and application would primarily depend on these chemical properties. Currently, there is limited data available on this particular chemical's use or hazards. It's vital to handle all such chemicals safely and with appropriate protective equipment, given the potential risks associated with exposure.

Upstream product

• 1032903-50-6 1-chloro-2-methyl-4-nitro-5-(propan-2-yloxy)benzene 
• 19524-06-2 4-bromopyridine hydrochloride 
• 73183-34-3 bis(pinacol)diborane 
• 1202858-68-1 1-bromo-5-isopropoxy-2-methyl-4-nitrobenzene 
• 1692-15-5 4-pyridylboronic acid 
• 64695-96-1 1-bromo-5-fluoro-2-methyl-4-nitrobenzene 
• 1422-53-3 2-bromo-4-fluorotoluene 
• 452-73-3 2-chloro-4-fluorotoluene 
• 112108-73-3 1-chloro-5-fluoro-2-methyl-4-nitrobenzene 

Downstream Products

• 1032903-65-3 4-(5-isopropoxy-2-methyl-4-nitrophenyl)-1-methyl-pyridinium iodide 
• 1035230-24-0 5-chloro-N²-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N⁴-((2-isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 
• 1032903-63-1 4-(4-amino-5-isopropoxy-2-methylphenyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 1032903-66-4 2-isopropoxy-5-methyl-4-(1-methyl-piperidin-4-yl)-phenylamine 
• 1380575-43-8 5-chloro-N²-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N⁴-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine hydrochloride 
• 1445894-96-1 N₂-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N₄-(2-(isopropylsulfonyl)phenyl)-5-methylpyrimidine-2,4-diamine 
• 1445894-97-2 5-chloro-N₄-(2-(cyclobutylsulfonyl)phenyl)-N₂-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)pyrimidine-2,4-diamine 
• 1445895-03-3 5-chloro-N₂-(2-isopropoxy-5-methyl-4-(1-ethylpiperidin-4-yl)phenyl)-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 
• 1445895-04-4 5-chloro-N₂-(2-isopropoxy-5-methyl-4-(1-isopropylpiperidin-4-yl)phenyl)-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 
• 1445895-08-8 5-chloro-N₂-(4-(1-(2,2-difluoroethyl)piperidin-4-yl)-2-isopropoxy-5-methylphenyl)-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 
• 1190399-47-3 1-(4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)-2-(dimethylamino)ethanone 
• 1445895-25-9 2-(4-(5-isopropoxy-4-((4-((2-(isopropylsulfonyl)phenyl)amino)-5-methylpyrimidin-2-yl)amino)-2-methylphenyl)piperidin-1-yl)ethanol 
• 1445895-27-1 N₂-(2-isopropoxy-4-(1-(2-methoxyethyl)piperidin-4-yl)-5-methylphenyl)-N₄-(2-(isopropylsulfonyl)phenyl)-5-methylpyrimidine-2,4-diamine 
• 1445894-99-4 4-bromo-5-chloro-N-(2-isopropoxy-5-methyl-4-(1-methylpiperidin-4-yl)phenyl)pyridin-2-amine 

Relevant articles and documents

Novel sulfinyl anilino pyrimidine derivative and application thereof in preparation of antitumor drugs

The invention relates to the field of medicines. A novel sulfinyl anilino pyrimidine derivative is disclosed, and the structural formula of the novel sulfinyl anilino pyrimidine derivative is as shown in the specification. Compared with an existing L858R/T790M inhibitor and EGFR / ALK double-target-target reference substance, the aniline-based pyrimidine derivative containing the sulfoxide group has better antitumor H 1975 activity compared with ALK the prior art BaF3 inhibitor and the EGFR/ALK double ALK-target reference substance. As proved by human liver microsomal experiments, the aniline-based pyrimidine derivatives containing the sulfoxide group in the invention are compared with the existing anisyl-containing anilino pyrimidine derivatives. There is a great increase in stability.

Chemical Process for Preparing Pyrimidine Derivatives and Intermediates Thereof

The present disclosure relates to a method of synthesizing 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine (ceritinib) and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing ceritinib.

Chemical Process for Preparing Pyrimidine Derivatives and Intermediates Thereof

The present disclosure relates to a method of synthesizing 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine (ceritinib) and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing ceritinib.