1033547-33-9

Basic information

• Product Name: 4-(p-tolyl)-2,6-bis(trifluoromethyl)pyridine
• Synonyms: 4-(p-tolyl)-2,6-bis(trifluoromethyl)pyridine
• CAS NO: 1033547-33-9
• Molecular Weight: 305.223
• Mol File: 1033547-33-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(p-tolyl)-2,6-bis(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(p-tolyl)-2,6-bis(trifluoromethyl)pyridine(1033547-33-9)
• EPA Substance Registry System: 4-(p-tolyl)-2,6-bis(trifluoromethyl)pyridine(1033547-33-9)

Safety Data

• Hazardous Substances Data: 1033547-33-9(Hazardous Substances Data)

Upstream product

• 96107-01-6 (E)-1,1,1,-trifluoro-4-(p-tolyl)but-3-en-2-one 
• 406951-57-3 diethyl (2-amino-3,3,3-trifluoroprop-1-enyl)phosphonate 
• 455-00-5 2,6-bis-(trifluoromethyl)pyridine 
• 106-38-7 para-bromotoluene 
• 1320747-32-7 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-bis(trifluoromethyl)pyridine 

Relevant articles and documents

Synthesis and Suzuki Cross-Coupling Reactions of 2,6-Bis(trifluoromethyl)pyridine-4-boronic Acid Pinacol Ester

Iridium-catalyzed aromatic borylation provides quick one-step access to 2,6-bis(trifluoromethyl)pyridine-4-boronic acid pinacol ester. Suzuki couplings of this highly electron-deficient pyridine-4-boronic ester with various (hetero)aryl bromides was successfully carried out and the coupled products were obtained in 46-95% isolated yields. Double and triple Suzuki couplings, with dibromo- and tribromoarenes, respectively, were also achieved. Thus demonstrating that this pyridine-4-boronic ester can be a useful source for the installation of one of the strongest electron-withdrawing aromatic group in organic compounds.