1033581-68-8Relevant articles and documents
Organometallic activation of a fluorogen for templated nucleic acid detection
Franzini, Raphael M.,Kool, Eric T.
, p. 2935 - 2938 (2008)
(Chemical Equation Presented) A nucleic acid detection scheme that employs DNA-mediated delivery of an organomercury activator to unmask a fluorophore is described. The approach relies on adjacent hybridization of two oligonucleotide conjugates containing organomercury and caged rhodamine functionalities. Postsynthetic conjugation of amino-modified DNAs enabled efficient preparation of these probes. Complementary DNA templates yielded fluorescence signals arising from metal-assisted rhodamine uncaging.