10336-29-5

Basic information

• Product Name: 8-Methyl-1-naphthalenemethanol
• Synonyms: 8-Methyl-1-naphthalenemethanol;(8-Methylnaphthalen-1-yl)methanol
• CAS NO: 10336-29-5
• Molecular Formula: C₁₂H₁₂O
• Molecular Weight: 172.22308
• Mol File: 10336-29-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 93-94.5 °C
• Boiling Point: 335.4±11.0 °C(Predicted)
• Appearance: /
• Density: 1.120±0.06 g/cm3(Predicted)
• PKA: 14.38±0.10(Predicted)
• CAS DataBase Reference: 8-Methyl-1-naphthalenemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Methyl-1-naphthalenemethanol(10336-29-5)
• EPA Substance Registry System: 8-Methyl-1-naphthalenemethanol(10336-29-5)

Safety Data

• Hazardous Substances Data: 10336-29-5(Hazardous Substances Data)

Usage

Description

8-Methyl-1-naphthalenemethanol is a synthetic chemical compound with the molecular formula C13H12O. It is an aromatic alcohol belonging to the class of naphthalene derivatives, known for its strong, floral odor.

Uses

Used in Perfume and Fragrance Industry:
8-Methyl-1-naphthalenemethanol is used as a raw material for creating perfumes, fragrances, and flavors due to its strong, floral scent.
Used in Personal Care Products:
8-Methyl-1-naphthalenemethanol is used as a component in personal care products for its pleasant aroma and ability to enhance the sensory experience of these products.
Used in Household Cleaners:
8-Methyl-1-naphthalenemethanol is used in the formulation of household cleaners to provide a fresh and floral scent, improving the overall user experience.
Used in Chemical Synthesis:
8-Methyl-1-naphthalenemethanol is used as a starting material in the synthesis of other chemicals, contributing to the production of various compounds.
Used in Disinfectants and Sanitizers:
8-Methyl-1-naphthalenemethanol is used in disinfectants and sanitizers due to its antimicrobial properties, helping to maintain cleanliness and hygiene.
It is important to handle and use 8-Methyl-1-naphthalenemethanol with care, as it may pose health and safety risks if not properly managed.

Upstream product

• 203-84-9 1H,3H-benzo[de]isochromene 
• 2026-08-6 naphthalene-1,8-diyldimethanol 
• 81-84-5 1,8-Naphthalic anhydride 
• 199988-50-6 (8-methoxymethyl-naphthalen-1-yl)-methanol 
• 19310-98-6 8-methyl-1-naphthoic acid 

Downstream Products

• 135734-04-2 1-(methoxymethyl)-8-methylnaphthalene 

Relevant articles and documents

Reductive cleavage of benzannelated cyclic ethers and amines: Synthetic applications

Reduction of symmetrical intramolecular diarylmethyl ethers (3a and 8a) and amines (3b and 8b) with alkali metals in THF allows the generation of unsymmetrical oxy- or amino-functionalised arylmethyl organometallics. Such intermediates were successfully trapped with various electrophiles, allowing a new access to unsymmetrically 2,2'-disubstituted-1,1'-biaryls (5aa-5bf) and 1,8-disubstituted naphthalenes (10aa-10be). (C) 2000 Elsevier Science Ltd.

New one-pot synthesis of a benzonorcaradiene derivative by reduction of naphthalic anhydride with LiAlH4

Reaction of naphthalic anhydride (naphthalene-1,8-dicarboxylic anhydride) (1) or of 1,8-bis(hydroxymethyl)naphthalene (3) with LiAlH4 in refluxing THF yields the benzonorcaradiene derivatives 2 in yields of up to 50%. It is proposed that in the formation of this (strained) product an anti-hydroalumination reaction is involved, which is facilitated by the assistance of a neighbouring alkoxide function.

HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are heterocyclyl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

HYDROXY ALKYL SUBSTITUTED 1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF ORL-1 RECEPTOR MEDIATED DISORDERS

The present invention is directed to novel hydroxy alkyl substituted 1, 3, 8-triazaspiro[4.5]decan-4-one derivatives of the general formula: wherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. More particularly, the compounds of the present invention are useful in the treatment of disorders and conditions such as anxiety, depression, panic, dementia, mania, bipolar disorder, substance abuse, neuropathic pain, acute pain, chronic pain migraine, asthma, cough, psychosis, schizophrenia, epilepsy, hypertension, obesity, eating disorders, cravings, diabetes, cardiac arrhythmia, irritable bowel syndrome, Crohn's disease, urinary incontinence, adrenal disorders, attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), Alzheimer's disease, for improved cognition or memory and for mood stabilization.