1033702-73-6Relevant articles and documents
Enantiocontrolled synthesis of (-)-9-epi-pentazocine and (-)-aphanorphine
Yang, Xiaobao,Zhai, Hongbin,Li, Zhong
supporting information; experimental part, p. 2457 - 2460 (2009/05/26)
(Chemical Equation Presented) We have developed novel asymmetric routes to (-)-9-epi-pentazocine and (-)-aphanorphine from a D-tyrosine derivative. The tricyclic frameworks of (-)-9-epi-pentazocine and (-)-aphanorphine were assembled stereoselectively via intramolecular Friedel-Crafts reaction of the corresponding bicyclic precursors, generated with titanium-promoted enyne cyclization and indium-initiated atom-transfer radical cyclization, respectively.