103441-05-0

Basic information

• Product Name: 1,3-Cyclohexadiene-1-carboxylic acid, 4,6,6-trimethyl-
• CAS NO: 103441-05-0
• Molecular Formula: C10H14O2
• Molecular Weight: 166.22
• Mol File: 103441-05-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,3-Cyclohexadiene-1-carboxylic acid, 4,6,6-trimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Cyclohexadiene-1-carboxylic acid, 4,6,6-trimethyl-(103441-05-0)
• EPA Substance Registry System: 1,3-Cyclohexadiene-1-carboxylic acid, 4,6,6-trimethyl-(103441-05-0)

Safety Data

• Hazardous Substances Data: 103441-05-0(Hazardous Substances Data)

Upstream product

• 124549-80-0 2β-Hydroxy-4,6,6-trimethylcyclohex-3-ene-1β-carboxylate 
• 78-59-1 3,5,5-Trimethylcyclohex-2-en-1-one 
• 41793-01-5 4,6,6-trimethyl-1,3-cyclohexadiene-1-carboxaldehyde 
• 179104-41-7 Methyl 4,6,6-trimethylcyclohexa-1,3-dienecarboxylate 
• 102720-24-1 Indole-3-magnesium iodide 
• 124549-81-1 2β-Benzoxy-4,6,6-trimethylcyclohex-3-ene-1β-carboxylic benzoic anhydride 
• 120-72-9 indole 
• 100520-15-8 4,6,6-trimethyl-cyclohexa-1,3-dienecarboxylic acid ethyl ester 

Downstream Products

• 179104-42-8 4,6,6-Trimethylcyclohexa-1,3-dienecarbonyl chloride 

Relevant articles and documents

Synthesis of inverto-yuehchukene and its 10-(indol-3′-yl) isomer. X-Ray structure of (4aRS,10aRS)-1,1,3-trimethyl-1,2,4a,5,10,10a-hexahydroindene[1,2-b]indol-10-one

A total synthesis of inverto-yuehchukene 4 and its 10-(indo-3′-yl) isomer 7 is described. The key tetracyclic ketone intermediate 13 was synthesized by a coupling reaction between 3-indolylzinc reagent and acid chloride 11, followed by Nazarov cyclization

A general approach to the total synthesis of yuehchukene and its analogues. A novel anti-implantation agent

A versatile synthetic strategy has been developed for the synthesis of the interesting dimeric indole natural product yuehchukene (17) and its epimer, 6a-epi-yuehchukene (22). Due to the anti-implantation activity associated with 17, it is important to develop a synthetic route not only to 17, but to a family of yuehchukene analogues with better chemical stability and/or elevated biological activity. The strategy described here and which utilizes the readily available and inexpensive isophorone (1) satisfies these requirements.