103492-33-7

Basic information

• Product Name: Hydrazinecarboxylic acid, 2-[[(4-chlorophenyl)amino]carbonyl]-, ethyl ester
• CAS NO: 103492-33-7
• Molecular Formula: C10H12ClN3O3
• Molecular Weight: 257.677
• Mol File: 103492-33-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Hydrazinecarboxylic acid, 2-[[(4-chlorophenyl)amino]carbonyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Hydrazinecarboxylic acid, 2-[[(4-chlorophenyl)amino]carbonyl]-, ethyl ester(103492-33-7)
• EPA Substance Registry System: Hydrazinecarboxylic acid, 2-[[(4-chlorophenyl)amino]carbonyl]-, ethyl ester(103492-33-7)

Safety Data

• Hazardous Substances Data: 103492-33-7(Hazardous Substances Data)

Upstream product

• 106-47-8 4-chloro-aniline 
• 7693-46-1 4-Nitrophenyl chloroformate 
• 4114-31-2 ethylhydrazine carboxylate 
• 3848-41-7 4-nitrophenyl (4-chlorophenyl)carbamate 
• 104-12-1 p-chlorphenylisocyanate 

Downstream Products

• 52039-87-9 4-(4-chlorophenyl)urazole 
• 1563536-53-7 N¹-(4-chlorophenyl)-N²-(pyridin-3-ylmethyl)diazene-1,2-dicarboxamide 
• 103492-32-6 ethyl 2-((4-chlorophenyl)carbamoyl)diazenecarboxylate 
• 1563536-47-9 N¹-(4-chlorophenyl)-N²-(pyridin-2-ylmethyl)diazene-1,2-dicarboxamide 
• 1563536-58-2 N¹-(4-chlorophenyl)-N²-(pyridin-4-ylmethyl)diazene-1,2-dicarboxamide 
• 1234426-80-2 6-(4-chlorophenyl)-3-dimethylamino-1,1,5,7-tetraoxo-1λ6-[1,2,4]triazolo[1,2-b][1,2,3,5]thiatriazole 

Relevant articles and documents

Microwave Assisted Synthesis of 4-Substituted 1-Ethoxycarbonyl Semicarbazides from Ethyl Carbazate and Isocyanates

A rapid and simple method for the preparation of 4-substituted 1-ethoxycarbonyl semi[0-9] carbazide is reported. The reaction is carried out under microwave irradiation by the reaction of five different isocyanates with ethyl carbazate.

Water-Involved Ring-Opening of 4-Phenyl-1,2,4-triazoline-3,5-dione for “Photo-Clicked” Access to Carbamoyl Formazan Photoswitches In Situ

Cyclic azodicarbonyl derivatives, particularly 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD), commonly serve as arenophile, dienophile, enophile and electrophile. Perplexed by its instability in aqueous environment, there are few studies focused on the transient intermediate produced by hydrolysis of PTAD to achieve synthetic significance. Herein, we describe a “photo-click” method that involves nitrile imine (NI) from diarylsydnone to capture the diazenecarbonyl-phenyl-carbamic acid (DACPA) generated by water-promoted ring-opening of PTAD. DFT calculation reveal that H-bonding interactions between PTAD and water are vital to form DACPA which exhibited an umpolung effect during ligation by nature bond orbit (NBO) analysis. The ultra-fast ligation resulted in carbamoyl formazans, as a unique Z?E photo-switchable linker on target molecules, including peptide and drugs, with excellent anti-fatigue performance. This strategy is showcased to construct highly functionalized carbamoyl formazans in situ for photo-pharmacology and material studies, which also expands the chemistry of PTAD in aqueous media.

Synthesis and biological activity of new diazenedicarboxamides as potential anticancer agents

To increase the effectiveness of cancer treatment, more effective anti-cancer drugs, as well as the new improved strategies of cancer treatment, are urgently needed. Our previous results have shown that various diazenes are cytotoxic to different tumor ce

N,N-Dialkyl-N′-chlorosulfonyl chloroformamidines in heterocyclic synthesis. part IX.* novel triazolo-fused thiatriazoles and pyrazolo-fused oxathiazines

N,N-dialkyl-N′-chlorosulfonyl chloroformamidines 1 reacted with 4-substituted urazoles 2 to give [1,2,4]triazolo[1,2-b] [1,2,3,5]thiatriazoles 3 in a selective 1,2-NN dinucleophilic mode of reaction.The reaction of 1 with N1-substituted pyrazol-5-ones 4 afforded pyrazolo[4,3-e][1,4,3] oxathiazines 5 via selective 1,3-CCO dinucleophilic substitution. Compounds 3 and 5 were the sole products isolated from the respective reactions and both represent new ring systems. CSIRO 2010.