1038915-92-2Relevant articles and documents
Indazole formamide compound as well as preparation method and application thereof
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Paragraph 0186; 0192-0193, (2021/02/16)
The invention belongs to the field of chemical medicines, and particularly relates to an indazole formamide compound as well as a preparation method and application thereof. The invention provides anindazole carboxamide compound or a pharmaceutically acce
Synthesis method for preparing PARP inhibitor Niraparib
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Paragraph 0041; 0042; 0043, (2017/08/28)
The invention provides a novel synthesis method for preparing a PARP inhibitor Niraparib. The method comprises the steps that a starting material methyl anthranilate is subjected to diazo coupling, cyclization, amidation, BOC removal and chiral resolution, and then the Niraparib with the purity reaching 99.5% is obtained. The method is simple, convenient and easy to operate suitable for industrial production.
Synthesis method of novel oral anticancer medicine Nirapairb
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Paragraph 0009; 0047; 0048; 0049; 0050, (2017/08/29)
The invention discloses a synthesis method of a novel oral anticancer medicine Nirapairb, the method comprises the following steps of subjecting a starting raw material 3-methyl-2-methyl bromobenzoate to a series of reactions of oxidization, aldimine condensation, cyclization, amidation, BOC (tert-Butyloxycarbonyl) removal, chiral separation and the like to obtain optically pure Niraparib of which the purity reaches 98.2 percent. The method is simple to operate, and is applicable to industrialized production; synthesis steps are few; a reaction condition is easily controlled.