1042318-27-3

Basic information

• Product Name: 5-(4-fluorophenyl)-2-propylthiazole
• Synonyms: 5-(4-fluorophenyl)-2-propylthiazole
• CAS NO: 1042318-27-3
• Molecular Weight: 221.298
• Mol File: 1042318-27-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5-(4-fluorophenyl)-2-propylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-fluorophenyl)-2-propylthiazole(1042318-27-3)
• EPA Substance Registry System: 5-(4-fluorophenyl)-2-propylthiazole(1042318-27-3)

Safety Data

• Hazardous Substances Data: 1042318-27-3(Hazardous Substances Data)

Upstream product

• 17626-75-4 2-(n-propyl)-thiazole 
• 460-00-4 1-Bromo-4-fluorobenzene 

Relevant articles and documents

Solvent-free palladium-catalyzed direct arylation of heteroaromatics with aryl bromides

Solvent is one of the major sources of waste in the course of catalyzed direct arylations. Some palladium-catalyzed direct arylations of heteroaromatics can be advantageously performed without any solvent. In the presence of palladium catalysts (1 mol%) and potassium acetate as the base, the direct 5-arylation of some thiazoles, thiophenes, furans, or pyrroles with aryl bromides as coupling partners proceeds highly regioselectively and in moderate to high yields. However, the use of these solvent-free conditions is limited to electron-deficient aryl bromides. Copyright

Cyclopentyl methyl ether: An alternative solvent for palladium-catalyzed direct arylation of heteroaromatics

Some ethers, such as cyclopentyl methyl ether and di-n-butyl ether, which can be considered as "greener" solvents than N,N-dimethylacetamide (DMAc) or DMF, can be advantageously employed for the palladium-catalyzed direct arylation of heteroaromatics. In the presence of such ethers and only 0.5-1 mol% of palladium catalysts at 125-150°C, the direct 5-arylation of thiazoles, thiophenes, or furans by using aryl bromides as coupling partners proceeds in moderate to high yields.