1042360-39-3

Basic information

• Product Name: methyl 3-(6-chloro-7-methyl-1,1-dioxo-1,4,2-benzothiazin-3-ylamino)-5-phenylthiophene-2-carboxylate
• CAS NO: 1042360-39-3
• Molecular Weight: 479.001
• Mol File: 1042360-39-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 3-(6-chloro-7-methyl-1,1-dioxo-1,4,2-benzothiazin-3-ylamino)-5-phenylthiophene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(6-chloro-7-methyl-1,1-dioxo-1,4,2-benzothiazin-3-ylamino)-5-phenylthiophene-2-carboxylate(1042360-39-3)
• EPA Substance Registry System: methyl 3-(6-chloro-7-methyl-1,1-dioxo-1,4,2-benzothiazin-3-ylamino)-5-phenylthiophene-2-carboxylate(1042360-39-3)

Safety Data

• Hazardous Substances Data: 1042360-39-3(Hazardous Substances Data)

Upstream product

• 100063-22-7 methyl 3-amino-5-phenylthiophene-2-carboxylate 

Downstream Products

• 1042360-64-4 C₂₆H₂₀ClN₃O₃S₃ 

Relevant articles and documents

Synthesis, anti-HIV-1 integrase, and cytotoxic activities of 4-chloro-N-(4-oxopyrimidin-2-yl)-2-mercaptobenzenesulfonamide derivatives

Several 4-chloro-N-(4-oxopyrimidin-2-yl)-2-mercaptobenzenesulfonamide derivatives 13-28 and 35-44 have been synthesized and tested as potential HIV-1 integrase (IN) inhibitors. Compounds 15-17, 19, 21-28, 36 and 41 inhibited IN with IC50 values in the range of 3.3-63.0 μM. The compounds 13, 15, 16, 21-24 and 26-28 were further tested at the US National Cancer Institute for their in vitro activity against a panel of 53-57 human tumor cell lines. The compounds 26-28 were inactive, whereas the other compounds exhibited high or reasonable activity (GI50 0.01-20.0 μM) against one or more human tumor cell lines.