104614-27-9

Basic information

• Product Name: 1-(prop-2-en-1-yloxy)-4-(trifluoromethyl)benzene
• Synonyms: 1-(prop-2-en-1-yloxy)-4-(trifluoromethyl)benzene
• CAS NO: 104614-27-9
• Molecular Weight: 202.176
• Mol File: 104614-27-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-(prop-2-en-1-yloxy)-4-(trifluoromethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(prop-2-en-1-yloxy)-4-(trifluoromethyl)benzene(104614-27-9)
• EPA Substance Registry System: 1-(prop-2-en-1-yloxy)-4-(trifluoromethyl)benzene(104614-27-9)

Safety Data

• Hazardous Substances Data: 104614-27-9(Hazardous Substances Data)

Upstream product

• 402-45-9 4-hydroxybenzotrifluoride 
• 107-05-1 3-chloroprop-1-ene 
• 106-95-6 allyl bromide 

Downstream Products

• 402-45-9 4-hydroxybenzotrifluoride 
• 198226-65-2 2-((4-(trifluoromethyl)phenoxy)methyl)oxirane 
• 724466-71-1 ethyl ((1S)-5-{3-[2-propyl-4-(trifluoromethyl)phenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl)acetate 
• 724466-70-0 2-propyl-4-(trifluoromethyl)phenol 
• 459432-59-8 2-(prop-2-en-1-yl)-4-(trifluoromethyl)phenol 

Relevant articles and documents

Nickel-catalyzed deallylation of aryl allyl ethers with hydrosilanes

An efficient and mild catalytic deallylation method of aryl allyl ethers is developed, with commercially available Ni(COD)2 as catalyst precursor, simple substituted bipyridine as ligand and air-stable hydrosilanes. The process is compatible with a variety of functional groups and the desired phenol products can be obtained with excellent yields and selectivity. Besides, by detection or isolation of key intermediates, mechanism studies confirm that the deallylation undergoes η3-allylnickel intermediate pathway.

Enantioselective Synthesis of 3-Fluorochromanes via Iodine(I)/Iodine(III) Catalysis

The chromane nucleus is common to a plenum of bioactive small molecules where it is frequently oxidized at position 3. Motivated by the importance of this position in conferring efficacy, and the prominence of bioisosterism in drug discovery, an iodine(I)/iodine(III) catalysis strategy to access enantioenriched 3-fluorochromanes is disclosed (up to 7:93 e.r.). In situ generation of ArIF2 enables the direct fluorocyclization of allyl phenyl ethers to generate novel scaffolds that manifest the stereoelectronic gauche effect. Mechanistic interrogation using deuterated probes confirms a stereospecific process consistent with a type IIinv pathway.

Enantioselective Construction of Si-Stereogenic Center via Rhodium-Catalyzed Intermolecular Hydrosilylation of Alkene

Catalytic, enantioselective synthesis of stereogenic silicon compounds remains a challenge. Herein, we report a rhodium-catalyzed regio- and enantio-selective intermolecular hydrosilylation of alkene with prochiral dihydrosilane. This new method features a simple catalytic system, mild reaction conditions and a wide functional group tolerance.