10468-72-1

Basic information

• Product Name: 1-([1,1'-biphenyl]-4-yl)cyclohexan-1-ol
• Synonyms: 1-([1,1'-biphenyl]-4-yl)cyclohexan-1-ol
• CAS NO: 10468-72-1
• Molecular Weight: 252.356
• Mol File: 10468-72-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-([1,1'-biphenyl]-4-yl)cyclohexan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-([1,1'-biphenyl]-4-yl)cyclohexan-1-ol(10468-72-1)
• EPA Substance Registry System: 1-([1,1'-biphenyl]-4-yl)cyclohexan-1-ol(10468-72-1)

Safety Data

• Hazardous Substances Data: 10468-72-1(Hazardous Substances Data)

Upstream product

• 3315-91-1 4-biphenylylmagnesium bromide 
• 108-94-1 cyclohexanone 
• 92-66-0 4-bromo-1,1'-biphenyl 

Downstream Products

• 125802-36-0 1-Biphenyl-4-yl-cyclohexylamine 
• 6301-53-7 3-(4-phenylphenyl)cyclohex-2-enone 
• 92-94-4 [1,1';4',1'']terphenyl 
• 92-92-2 biphenyl-4-carboxylic acid 
• 415898-21-4 7-oxa-1-(4-phenylphenyl)bicyclo[4.1.0]heptane 
• 5452-64-2 4-cyclohex-1-enyl-biphenyl 

Relevant articles and documents

Remote Nickel-Catalyzed Cross-Coupling Arylation via Proton-Coupled Electron Transfer-Enabled C-C Bond Cleavage

Cross-coupling reactions for carbon-carbon and carbon-heteroatom bond formation are of great importance in modern chemical synthesis. In addition to classical cross-couplings involving preformed or preactivated coupling partners, more recently breakthroughs have been made in the selective, direct coupling of abundant aliphatic carbon-hydrogen bonds using hydrogen atom transfer reactions in which the bond-dissociation energy is the thermodynamic driving force. The more challenging carbon-carbon bond activation is still rather underdeveloped due to the bond inertness. Herein, we report a mild and general strategy for the activation of a diverse set of readily available cyclic alcohols for the remote and site-specific arylation of ketones via the combination of photoredox-mediated multisite concerted proton-electron transfer (MS-PCET) and nickel catalysis. The current cross-coupling proceeds with the generation of an alkoxy radical utilizing bond-dissociation free energy (BDFE) as the thermodynamic driving force. Subsequently, the resulting remote carbon-centered radicals formed by C-C cleavage merge with the nickel catalytic cycle to create the challenging C(sp3)-C(sp2) bonds.

Synthesis and Anticonvulsant Activity of 1-Phenylcyclohexylamine Analogues

Thirty-eight analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, were examined for their activities in the mouse maximal electroshock (MES) seizure test and in a motor-toxicity assay.In addition, we determined the binding affinities of the compounds for PCP acceptor sites in rat brain membranes labeled with -1-piperidine.Many of the analogues were protective against MES seizures (ED50s of 4-41 mg/kg, ip) and all of these compounds caused motor toxicity.The potencies in the motor toxicity and MES seizure tests showed a moderate correlation with the affinities for PCP sites.Several analogues exhibited a greater separation of potencies in the motor toxicity and MES seizure tests than did the parent compound PCA.These were obtained by (i) 3-methylation of the cyclohexyl ring trans to the phenyl ring, (ii) methoxylation at the ortho position on the phenyl ring, and (iii) contraction of the cyclohexane ring to form the corresponding cyclopentane.