10512-65-9 Usage
General Description
2H-1,3-Benzothiazine-2,4(3H)-dione, also known as riluzole, is a chemical compound that is used primarily as a treatment for amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease. It works by reducing the release of glutamate, a neurotransmitter that can contribute to the death of nerve cells. Riluzole is believed to help slow the progression of ALS by protecting against nerve cell damage. It has also been studied for its potential use in treating other neurological disorders, such as Parkinson's disease and multiple sclerosis. Riluzole is available in tablet form for oral administration and is generally well-tolerated by most patients, although it can have side effects such as nausea, dizziness, and weakness. Overall, riluzole represents an important therapeutic option for those with ALS and shows promise for future applications in the treatment of other neurological conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 10512-65-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,5,1 and 2 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 10512-65:
(7*1)+(6*0)+(5*5)+(4*1)+(3*2)+(2*6)+(1*5)=59
59 % 10 = 9
So 10512-65-9 is a valid CAS Registry Number.
10512-65-9Relevant articles and documents
Alkylation of 1,3-benzothiazin-4-one 2-oxo-, 2-arylimino-, and 2-thioxo derivatives
Shestakov, Alexandr S.,Prezent, Mikhail A.,Zlatoustovskaya, Evgenia O.,Shikhaliev, Khidmet S.,Falaleev, Alexandr V.,Sidorenko, Oleg E.
, p. 370 - 376 (2016/01/12)
[Figure not available: see fulltext.] Sodium salt of 3H -benzo[e][1,3]thiazine-2,4-dione is easily alkylated at position 3. In the case of 2-(arylimino)-2,3-dihydrobenzo[e][1,3]-thiazin-4-ones, the alkylation reaction at this position occurs regioselectively. Alkylation of 2-thioxo-2,3-dihydrobenzo[e][1,3]thiazin-4-one under the same conditions produced regioisomers, but S-alkylation at the exocyclic sulfur atom occurred in the presence of triethylamine. The reaction of 1-(4-oxo-3,4-dihydrobenzo[e][1,3]thiazin-2-ylidene)guanidine with methyl anthranilate led to the formation of tetracyclic quinazolino[2,1-b]quinazolinedione.
