10524-06-8 Usage
Description
(1-chloroethyl)cyclopropane is an organochlorine compound that features a cyclopropane ring and a chloroethyl group. It is utilized as a versatile building block in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new and improved products in these fields.
Uses
Used in Pharmaceutical Synthesis:
(1-chloroethyl)cyclopropane is used as a key intermediate in the production of pharmaceuticals for its ability to be readily incorporated into complex molecular structures. This allows for the creation of novel drug candidates with potential therapeutic benefits.
Used in Agrochemical Production:
In the agrochemical industry, (1-chloroethyl)cyclopropane is used as a starting material for the synthesis of various agrochemicals, such as pesticides and herbicides. Its reactivity and stability make it a valuable component in developing effective and targeted crop protection solutions.
Safety Precautions:
Due to its flammable nature and potential to cause irritation to the skin, eyes, and respiratory system, (1-chloroethyl)cyclopropane requires careful handling and the use of appropriate safety measures. Protective equipment, such as gloves, goggles, and respirators, should be worn when working with this chemical to minimize the risk of exposure and ensure the safety of those involved in its production and use.
Check Digit Verification of cas no
The CAS Registry Mumber 10524-06-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,5,2 and 4 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 10524-06:
(7*1)+(6*0)+(5*5)+(4*2)+(3*4)+(2*0)+(1*6)=58
58 % 10 = 8
So 10524-06-8 is a valid CAS Registry Number.
10524-06-8Relevant articles and documents
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Meshcheryakov,A.P.,Glukhovtsev,V.G.
, (1961)
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Electrophilic cleavage of cyclopropylmethystannanes: An experimental comparison of σ-σ and σ-π conjugation
Lucke, Andrew J.,Young, David J.
, p. 3579 - 3583 (2007/10/03)
(Chemical Equation Presented) Cyclopropylmethyltrimethylstannanes undergo electrophilic cyclopropane cleavage in chloroform with simple inorganic electrophiles (H+, SO2, I2) in a homologous reaction to the SE′ cleavage of allylic stannanes. The σ-σ conjugation between the carbon-tin bond and cyclopropane orbitals observed spectroscopically in the parent cyclopropylmethyltrimethylstannane is responsible for a rate enhancement of ca. 102 toward iodinolysis, relative to comparable alkyl stannanes. This acceleration is considerably less, however, than the ca. 109-fold rate enhancement provided by the corresponding σ-π conjugation in allylic stannanes. Methanol-tin coordination appears to reduce the activating influence of the metal, promoting methyl cleavage over cyclopropane fission with acid and iodine. Decreased σ-σ conjugation can also explain the decreased reactivity of cyclopropyltriphenylstannane compared with its trimethyltin counterpart. Cyclopropylmethylstannanes do not undergo the synthetically useful addition of aldehydes under conditions that facilitate the corresponding reaction of allylic stannanes.
AN IMPROVED, PREPARATIVE ROUTE TO 1-CYCLOPROPYL-1-HALOETHANES
Hrubiec, Robert T.,Smith, Michael B.
, p. 593 - 600 (2007/10/02)
We wish to report a method for the synthesis of 1-cyclopropyl-1-chloroethane and 1-cyclopropyl-1-bromoethane, on a preparative scale, uncontaminated by 5-chloro(or bromo)-2-pentene.
