105250-17-7

Basic information

• Product Name: (2-AMINO-PYRIDIN-4-YL)-METHANOL
• Synonyms: 2-AMINO-4-PYRIDINEMETHANOL;(2-AMINO-PYRIDIN-4-YL)-METHANOL;2-AMINOPYRIDINE-4-METHANOL;2-Amino-4-hydroxymethylpyridine;4-Pyridinemethanol,2-amino-(9CI);2-Amino-4-pyridinylmethanol;(2-Amino-pyridin-4-yl)-methanol ,97%;(2-amino-4-pyridinyl)methanol(SALTDATA: FREE)
• CAS NO: 105250-17-7
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.14
• EINECS: -0
• Product Categories: PYRIDINE;pharmacetical;Pyridine series
• Mol File: 105250-17-7.mol
• Article Data: 18

Chemical Properties

• Melting Point: 43-44°C
• Boiling Point: 329.508 °C at 760 mmHg
• Flash Point: 153.081 °C
• Appearance: White to yellow/Crystalline Powder
• Density: 1.257 g/cm³
• Vapor Pressure: 7.1E-05mmHg at 25°C
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 13.37±0.10(Predicted)
• Water Solubility: Soluble in water.
• Sensitive: Air Sensitive
• BRN: 8760550
• CAS DataBase Reference: (2-AMINO-PYRIDIN-4-YL)-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (2-AMINO-PYRIDIN-4-YL)-METHANOL(105250-17-7)
• EPA Substance Registry System: (2-AMINO-PYRIDIN-4-YL)-METHANOL(105250-17-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 105250-17-7(Hazardous Substances Data)

Usage

Description

(2-AMINO-PYRIDIN-4-YL)-METHANOL, also known as 2-Aminopyridine-4-methanol, is an organic compound with the molecular formula C6H8N2O. It is a light yellow crystalline substance that serves as a crucial intermediate in the pharmaceutical industry due to its unique chemical properties and reactivity.

Uses

Used in Pharmaceutical Industry:
(2-AMINO-PYRIDIN-4-YL)-METHANOL is used as a pharmaceutical intermediate for the synthesis of various drugs and medications. Its presence in the molecular structure of these drugs contributes to their therapeutic effects and pharmacological properties, making it an essential component in the development of novel pharmaceuticals.
Chemical Properties:
(2-AMINO-PYRIDIN-4-YL)-METHANOL exhibits light yellow crystalline characteristics, which are indicative of its solid-state structure and stability. These properties are essential for its use in the pharmaceutical industry, as they allow for easy handling, storage, and incorporation into drug formulations.

InChI:InChI=1/C6H8N2O/c7-6-3-5(4-9)1-2-8-6/h1-3,9H,4H2,(H2,7,8)/p+1

Upstream product

• 13362-30-6 2-amino-4-ethoxycarbonyl-pyridine 
• 872706-97-3 4-(chloromethyl)pyridin-2-amine 
• 53547-60-7 4-methyl-2-pyridinecarbaldehyde 
• 119646-48-9 4-hydroxymethyl-2-pyridinecarboxamide 
• 13362-28-2 2-aminoisonicotinic acid 
• 929899-48-9 2-amino-isonicotinic acid ethyl ester bishydrochloride 
• 6937-03-7 methyl 2-aminoisonicotinate 
• 54221-95-3 2-(acetylamino)isonicotinic acid 
• 5327-32-2 2-acetylamino-4-methylpyridine 
• 695-34-1 2-Amino-4-methylpyridine 
• 304873-62-9 (4-hydroxymethylpyridin-2-yl)carbamic acid tert-butyl ester 

Downstream Products

• 342613-80-3 7-hydroxymethylimidazo[1,2-a]pyridine 
• 864494-46-2 2-(2-aminopyridin-4-ylmethylthio)-N-(3,5-dimethylphenyl)pyridine-3-carboxamide 
• 1311991-78-2 (3-(cyclohexylamino)-2-(4-methoxyphenyl)imidazo[1,2-a]pyridine-7-yl)methanol 
• 1338053-34-1 N-(4-(((4-(3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)methyl)pyridin-2-yl)acetamide 
• 1220627-08-6 1-(4-((2-aminopyridin-4-yl)methoxy)naphthalen-1-yl)-3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea 
• 1337932-11-2 4-((2,3-dichloro-4-nitrophenoxy)methyl)pyridin-2-amine 
• 1337932-07-6 N-(4-((2,3-dichloro-4-nitrophenoxy)methyl)pyridin-2-yl)-2-methoxyacetamide 
• 1337932-08-7 N-(4-((2,3-dichloro-4-aminophenoxy)methyl)pyridin-2-yl)-2-methoxyacetamide 
• 1337930-84-3 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(8-[(2-(3-methylureido)pyridin-4-yl)methoxy]quinolin-5-yl)urea 
• 1337930-83-2 N-(4-((4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)methyl)pyridin-2-yl)pyrrolidine-1-carboxamide 
• 1337930-82-1 N-(4-((4-(3-(3-tert-butyl-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)methyl)pyridin-2-yl)pyrrolidine-1-carboxamide 
• 1337930-81-0 1-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)-3-(2,3-dichloro-4-(2-(3-methylureido)pyridin-4-yl)methoxyphenyl)urea 

Relevant articles and documents

New method for preparation of (2-aminopyridin-4-yl)methanol

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Method for synthesizing 2-aminopyridine-4-methanol

The invention discloses a method for synthesizing 2-aminopyridine-4-methanol. The method comprises the following steps that 4-pyridylcarbinol reacts with an aqueous formamide solution to prepare a second compound; the second compound and a NaOH solution are mixed and placed into a reaction still, the temperature is controlled within 5-10 DEG C, a NaBrO solution is added dropwise into the reactionstill, after the dropwise addition is completed, the reaction is continuously conducted for 1-2 hours at the temperature, then the temperature is raised to 50-60 DEG C to enable the reaction to be conducted continuously for 1 hour and then reduced to room temperature, ethyl acetate is used for carrying out extraction several times, organic phases are combined, distillation under reduced pressure is conducted to remove ethyl acetate, and 2-aminopyridine-4-methanol is prepared. The synthesis method has the advantages that the operation is simple, the conditions are mild, few byproducts are generated, and the product purity and yield are high.

NOVEL COMPOUND, ORGANIC CATION TRANSPORTER 3 DETECTION AGENT, AND ORGANIC CATION TRANSPORTER 3 ACTIVITY INHIBITOR

[Problem] The present invention addresses the problem of providing a novel compound. The present invention also addresses the problem of providing an OCT3 detection agent or an OCT3 activity inhibitor, which comprises the novel compound. [Solution] A compound represented by formula (A), a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof. ????????R1-R2-R3-R4?????(A)