10543-42-7 Usage
Description
COUMARIN-6-SULFONYL CHLORIDE is an organic compound that is commonly utilized in the field of chemistry for various labeling and derivatization purposes. It is known for its ability to react with amines, amino acids, and phenols under mild conditions, making it a versatile reagent in chemical synthesis and analysis.
Uses
Used in Chemical Synthesis:
COUMARIN-6-SULFONYL CHLORIDE is used as a labeling agent for amines, amino acids, and phenols. This application is particularly useful in the identification and tracking of these molecules in various chemical and biological processes. The mild conditions required for the reaction make it a preferred choice for preserving the integrity of sensitive molecules.
Used in Derivatization:
COUMARIN-6-SULFONYL CHLORIDE is also used as a derivatizing agent for amines and phenols. This process involves the chemical modification of these molecules to enhance their properties or to facilitate their analysis. The derivatization can improve the solubility, stability, or detectability of the target molecules, making it easier to study their behavior in different environments.
Check Digit Verification of cas no
The CAS Registry Mumber 10543-42-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,5,4 and 3 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 10543-42:
(7*1)+(6*0)+(5*5)+(4*4)+(3*3)+(2*4)+(1*2)=67
67 % 10 = 7
So 10543-42-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H5ClO4S/c10-15(12,13)7-2-3-8-6(5-7)1-4-9(11)14-8/h1-5H
10543-42-7Relevant articles and documents
Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies
Sabt, Ahmed,Abdelhafez, Omaima M.,El-Haggar, Radwan S.,Madkour, Hassan M. F.,Eldehna, Wagdy M.,El-Khrisy, Ezz El-Din A. M.,Abdel-Rahman, Mohamed A.,Rashed, Laila. A.
, p. 1095 - 1107 (2018)
Herein, we report the synthesis of different novel sets of coumarin-6-sulfonamide derivatives bearing different functionalities (4a, b, 8a–d, 11a–d, 13a, b, and 15a–c), and in vitro evaluation of their growth inhibitory activity towards the proliferation of three cancer cell lines; HepG2 (hepatocellular carcinoma), MCF-7 (breast cancer), and Caco-2 (colon cancer). HepG2 cells were the most sensitive cells to the influence of the target coumarins. Compounds 13a and 15a emerged as the most active members against HepG2 cells (IC50 = 3.48 ± 0.28 and 5.03 ± 0.39 μM, respectively). Compounds 13a and 15a were able to induce apoptosis in HepG2 cells, as assured by the upregulation of the Bax and downregulation of the Bcl-2, besides boosting caspase-3 levels. Besides, compound 13a induced a significant increase in the percentage of cells at Pre-G1 by 6.4-folds, with concurrent significant arrest in the G2-M phase by 5.4-folds compared to control. Also, 13a displayed significant increase in the percentage of annexin V-FITC positive apoptotic cells from 1.75–13.76%. Moreover, QSAR models were established to explore the structural requirements controlling the anti-proliferative activities.