105946-57-4Relevant articles and documents
Amide-assisted rearrangement of hydroxyarylformimidoyl chloride to diarylurea
Jin, Yi,Liu, Xiaoyu,Song, Xizhong,Yu, Wei
supporting information, (2021/11/11)
A novel amide-assisted rearrangement reaction of hydroxybenzimidoyl chloride has been established for the efficient synthesis of 1,3-diphenylurea derivatives. A variety of electronically and sterically different 1,3-diphenylurea derivatives can be obtained in good to excellent yields, and a proposed reaction mechanism is also presented.
Effective approach to ureas through organocatalyzed one-pot process
Wang, Mingliang,Han, Jilai,Si, Xiaojia,Hu, Yimin,Zhu, Jidong,Sun, Xun
supporting information, p. 1614 - 1618 (2018/03/28)
An efficient approach to N, N′-unsymmetrically substituted ureas 9 has been developed through the ammonolysis process of N-Boc protected anilines 7 with amines prompted by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD). Moreover, a convenient protocol for the
Influence of polarity on the scalability and reproducibility of solvent-free microwave-assisted reactions
Diaz-Ortiz, Ange,De La Hoz, Antonio,Alcazar, Jesus,Carrillo, Jose R.,Herrero, Maria A.,Fontana, Alberto,Munoz, Juan De M.,Prieto, Pilar,De Cozar, Abel
experimental part, p. 109 - 116 (2012/04/18)
Organic reactions performed in the absence of solvent in domestic ovens without appropriate temperature control are generally considered as not reproducible, particularly when different instruments are used. For this reason, reproducibility has historically been one of the major issues associated with Microwave-Assisted Organic Synthesis (MAOS) especially when domestic ovens are involved. The lack of reproducibility limits the general applicability and the scale up of these reactions. In this work several solvent-free reactions previously carried out in domestic ovens have been translated into a single-mode microwave reactor and then scaled up in a multimode oven. The results show that most of these reactions, although not considered as reproducible, can be easily updated and applied in microwave reactors using temperature-controlled conditions. Furthermore, computational calculations can assist to explain and/or predict whether a reaction will be reproducible or not.
