1061-64-9 Usage
Description
(3a,5b,7a,12a)3,7,12,24-tetrahydroxy-cholestan-26-oic acid is a bile acid derivative of cholic acid, characterized by its four hydroxyl groups at positions 3, 7, 12, and 24 on the cholestane backbone, and a carboxylic acid group at position 26. It plays a vital role in digestion and absorption of dietary fats, emulsifying and solubilizing lipid molecules in the intestines, and acts as a signaling molecule to regulate bile acid synthesis and metabolism, thus maintaining lipid and cholesterol homeostasis in the body.
Uses
Used in Pharmaceutical Industry:
(3a,5b,7a,12a)3,7,12,24-tetrahydroxy-cholestan-26-oic acid is used as a therapeutic agent for treating conditions related to lipid and cholesterol imbalances, such as hypercholesterolemia and fatty liver disease. Its role in regulating bile acid synthesis and metabolism makes it a potential candidate for managing these conditions.
Used in Nutritional Supplements:
In the dietary supplement industry, (3a,5b,7a,12a)3,7,12,24-tetrahydroxy-cholestan-26-oic acid can be used as an ingredient to support healthy digestion and absorption of dietary fats, promoting overall lipid homeostasis and contributing to general well-being.
Used in Research and Development:
(3a,5b,7a,12a)3,7,12,24-tetrahydroxy-cholestan-26-oic acid is utilized in research and development for studying the mechanisms of bile acid synthesis, metabolism, and their impact on lipid and cholesterol homeostasis. This knowledge can lead to the development of new therapeutic strategies for related health conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1061-64-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,6 and 1 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1061-64:
(6*1)+(5*0)+(4*6)+(3*1)+(2*6)+(1*4)=49
49 % 10 = 9
So 1061-64-9 is a valid CAS Registry Number.
InChI:InChI=1/C27H46O6/c1-14(5-8-21(29)15(2)25(32)33)18-6-7-19-24-20(13-23(31)27(18,19)4)26(3)10-9-17(28)11-16(26)12-22(24)30/h14-24,28-31H,5-13H2,1-4H3,(H,32,33)/t14-,15?,16+,17-,18-,19+,20+,21?,22-,23+,24+,26+,27-/m1/s1
1061-64-9Relevant articles and documents
IMPROVED SYNTHESIS OF 3α,7α,12α,24ξ-TETRAHYDROXY-5β-CHOLESTAN-26-OIC ACID
Batta, A. K.,Tint, G. S.,Dayal, B.,Shefer, S.,Salen, G.
, p. 693 - 702 (1982)
This paper describes three simple and short methods for the conversion of cholic acid into cholylaldehyde with protected hydroxyl groups.The first method involves lithium aluminium hydride reduction of the tetrahydropyranyl ether of methyl cholate and oxidation of the resulting primary alcohol with pyridinium chlorochromate.The second method employs diborane for the reduction of the -COOH group to the -CH2OH group, while the third method involves the reduction of 3α,7α,12α-triformyloxy-5β-cholan-24-oic acid (as the acid chloride) directly into 3α,7α,12α-triformyloxy-5β-cholan-24-al with TMA-ferride (tetramethylammonium hydridoirontetracarbonyl).The aldehyde obtained by any of the above methods underwent smooth Reformatsky reaction with ethyl α-bromopropionate to yield 3α,7α,12α,24ξ-tetrahydroxy-5β-cholestan-26-oic acid.
