107444-51-9 Usage
Description
GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN is a natural gastrointestinal peptide derived from proglucagon and is metabolically inactive. It is processed into two smaller amide forms, GLP-1 (7-37) amide and GLP-1 (7-36) amide, and plays a crucial role in the hormonal control of insulin secretion.
Uses
Used in Pharmaceutical Industry:
GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN is used as a GLP-1 receptor agonist for various applications, including:
1. In lysate transfer cyclic adenosine monophosphate (cAMP) assay to test its effect on adenylyl cyclase activity.
2. To pre-treat human umbilical vein endothelial cells (HUVECs) to monitor its effect on hyperpermeability in endothelial cell (EC) monolayers and changes with the actin cytoskeleton.
3. To test its inhibitory effect on vascular endothelial growth factor-A (VEGFA) based vasodilation in rat mesenteric arteries.
Used in Diabetes Research:
GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN is used as an effector in the hormonal control of insulin secretion. The peptide fragment is secreted from the lower small intestine, and its action is mediated by receptors expressed by the endocrine pancreatic B-cells. However, it is not yet an approved application for Diabetes Type II treatment.
Biochem/physiol Actions
GLP-1 (glucagon-like peptide 1) (7-36) amide is a potent insulinotropic peptide, which initiates the glucose-induced insulin release after meals or oral glucose intake. It has an anti-diabetogenic effect and thus, might have use in the treatment of non-insulin dependent diabetes mellitus.
Check Digit Verification of cas no
The CAS Registry Mumber 107444-51-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,4,4 and 4 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 107444-51:
(8*1)+(7*0)+(6*7)+(5*4)+(4*4)+(3*4)+(2*5)+(1*1)=109
109 % 10 = 9
So 107444-51-9 is a valid CAS Registry Number.