107469-64-7Relevant articles and documents
Expanding the chemical space of 3(5)-functionalized 1,2,4-triazoles
Khomenko, Dmytro M.,Doroshchuk, Roman O.,Ohorodnik, Yulia M.,Ivanova, Hanna V.,Zakharchenko, Borys V.,Raspertova, Ilona V.,Vaschenko, Oleksandr V.,Dobrydnev, Alexey V.,Grygorenko, Oleksandr O.,Lampeka, Rostyslav D.
, p. 116 - 128 (2022/03/31)
[Figure not available: see fulltext.] An efficient approach to the gram-scale synthesis of 3(5)-substituted, 1,3- and 1,5-disubstituted 1,2,4-triazole-derived building blocks is described. The key synthetic precursors – 1,2,4-triazole-3(5)-carboxylates (2
HETEROCYCLIC AMIDES AS KINASE INHIBITORS
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Page/Page column 93, (2018/09/26)
Disclosed is a combination of a RIP1 kinase inhibitor compound and at least one other therapeutically active agent for use in the treatment of a RIP1 kinase mediated disease or disorder; particularly disclosed is a combination of a RIP1 kinase inhibitor compound and at least one other therapeutically active agent, wherein the at least one other therapeutically active agent is an immuno-modulator, for use in the treatment of cancer.
HETEROCYCLIC AMIDES AS KINASE INHIBITORS
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Page/Page column 117, (2014/09/03)
Disclosed are compounds having the formula (I) wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.