108052-76-2

Basic information

• Product Name: 4-(BROMOMETHYL)-BENZOIC ACID, 1,1-DIMETHYLETHYL ESTER
• Synonyms: 4-(BROMOMETHYL)-BENZOIC ACID, 1,1-DIMETHYLETHYL ESTER;4-BROMO METHYL BENZOIC ACID MONO TERT-BUTYL ESTER;TERT-BUTYL P-(BROMOMETHYL) BENZOATE;4-Bromomethyl-benzoic acid tert-butyl ester;t-butyl-4-bromomethylbenzoate;1,1-DIMETHYLETHYL 4-(BROMOMETHYL)BENZOATE;tert-Butyl 4-(bromomethyl)benzoate;4-Benzoic acid mono tert-butyl ester
• CAS NO: 108052-76-2
• Molecular Formula: C₁₂H₁₅BrO₂
• Molecular Weight: 271.15
• EINECS: 1312995-182-4
• Mol File: 108052-76-2.mol
• Article Data: 36

Chemical Properties

• Melting Point: 53-55 °C
• Boiling Point: 320.936 °C at 760 mmHg
• Flash Point: 147.897 °C
• Appearance: white crystal powder
• Density: 1.314 g/cm³
• Vapor Pressure: 0.000308mmHg at 25°C
• Refractive Index: 1.537
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-(BROMOMETHYL)-BENZOIC ACID, 1,1-DIMETHYLETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(BROMOMETHYL)-BENZOIC ACID, 1,1-DIMETHYLETHYL ESTER(108052-76-2)
• EPA Substance Registry System: 4-(BROMOMETHYL)-BENZOIC ACID, 1,1-DIMETHYLETHYL ESTER(108052-76-2)

Safety Data

• Hazardous Substances Data: 108052-76-2(Hazardous Substances Data)

Usage

General Description

4-(Bromomethyl)-benzoic acid, 1,1-dimethylethyl ester is a chemical compound often used in the field of organic chemistry. The substance, classified as an ester, is recognized for its bromomethyl and benzoic acid components. The compound is distinguished by the presence of a bromomethyl group (-CH2Br) attached to the fourth carbon of the benzene ring in the benzoic acid molecule, and a 1,1-dimethylethyl ester group. 4-(BROMOMETHYL)-BENZOIC ACID, 1,1-DIMETHYLETHYL ESTER is commonly used as a reagent or intermediate in various chemical reactions, especially in the synthesis of other organic compounds. As with all chemicals, it should be handled with care due to potential health and safety risks.

InChI:InChI=1/C12H15BrO2/c1-12(2,3)15-11(14)10-6-4-9(8-13)5-7-10/h4-7H,8H2,1-3H3

Upstream product

• 13756-42-8 tert-butyl 4-methylbenzoate 
• 6232-88-8 4-bromomethylbenzoic Acid 
• 115-11-7 isobutene 
• 52780-16-2 4-bromomethylbenzoyl chloride 
• 865-47-4 potassium tert-butylate 
• 99-94-5 p-Toluic acid 
• 874-60-2 4-methyl-benzoyl chloride 
• 98946-18-0 tert-Butyl 2,2,2-trichloroacetimidate 
• 4885-02-3 Dichloromethyl methyl ether 
• 75-65-0 tert-butyl alcohol 
• 71432-55-8 2-tert-butyl-1,3-diisopropylisourea 
• 540-88-5 acetic acid tert-butyl ester 
• 15679-00-2 tert-butyl 2,2,2-trichloroacetimidate 
• 876-07-3 4-(bromomethyl)benzoyl bromide 

Downstream Products

• 126062-58-6 dimethyl<4-(tert-butoxycarbonyl)benzyl><(trimethylsilyl)methyl>ammonium bromide 
• 127153-49-5 (+/-)-4-<(1,1-dimethylethoxy)carbonyl>-α-<(diphenylmethylene)amino>benzenepropanoic acid phenylmethyl ester 
• 1064666-73-4 4-(2-(Dimethyl-hydrazonomethyl)-6-{4-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-phenyl}-hexyl)-benzoic acid tert-butyl ester 
• 1064666-75-6 4-(2-(Dimethyl-hydrazonomethyl)-7-{4-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-phenyl}-heptyl)-benzoic acid tert-butyl ester 
• 118507-44-1 t-butyl 4-fluoromethylbenzoate 
• 528598-97-2 tert-butyl 4-(3-formyl-4-methoxyphenoxymethyl)benzoate 
• 947756-82-3 tert-butyl 4-[2-(dimethylamino)-3-ethoxy-3-oxopropyl]benzoate 
• 1062142-22-6 C₄₁H₄₈O₇ 
• 1312612-73-9 4-[2-(4-nitrophenyl)ethenyl]benzoic acid tert-butyl ester 
• 1312612-74-0 4-[2-(4-aminophenyl)ethyl]benzoic acid tert-butyl ester 
• 1312612-75-1 4-{2-[4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)phenyl]ethyl}benzoic acid tert-butyl ester 
• 1312612-72-8 4-{2-[4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)phenyl]ethyl}benzoic acid 
• 1326778-79-3 C₂₆H₃₆N₂O₃ 
• 1326778-80-6 C₃₇H₄₉N₃O₄ 

Relevant articles and documents

Investigation of the Stereoselective Synthesis of the Indane Dimer PH46A, a New Potential Anti-inflammatory Agent

PH46A, belonging to a class of 1,2-Indane dimers, has been developed by our research group as a potential therapeutic agent for the treatment of inflammatory and autoimmune diseases. The initial synthetic route to PH46A gave a low overall yield, due in la

Acid-Stable Ester Linkers for the Solid-Phase Synthesis of Immobilized Peptides

A series of N-terminally Fmoc-protected linkers of the general formula Fmoc-X?CO?O?Y?COOH have been prepared, where X is ?NH?CH2?CH2- or -p-(aminomethyl)phenyl- and Y is ?(CH2)n? (n is 1 or 4) or -p-(methyl)phenyl-. These linkers can easily be covalently attached via their C-terminal carboxyl group to a resin bearing a free amino group. After cleavage of the N-terminal Fmoc group, the linkers can be extended by standard solid-phase peptide synthesis techniques. These ester linkers are acid-stable and resistant to the base-mediated diketopiperazine formation that often occurs during the synthesis of ester-bound peptides; they are stable at neutral pH in aqueous buffers for days but can be effectively cleaved with 0.1 m NaOH or aq. ammonia within minutes or hours, respectively. These properties make these ester handles well suited for use as linkers for the solid-phase peptide synthesis of immobilized peptides when the stable on-resin immobilization of the peptides and the testing of their biological properties in aqueous buffers at neutral pH are necessary.

3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF

The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein R1, R2, Rx, X1, n, n1, and q are as defined herein, and methods of making and using same.