108294-53-7 Usage
Description
P-IODOCLONIDINE HYDROCHLORIDE is an α2-Adrenergic agonist that exhibits a high affinity for the α2-adrenergic receptor. It is a pharmaceutical compound with various applications in different industries due to its ability to interact with specific receptors in the body.
Uses
Used in Pharmaceutical Industry:
P-IODOCLONIDINE HYDROCHLORIDE is used as a therapeutic agent for its ability to stimulate the α2-adrenergic receptor. This interaction can lead to various pharmacological effects, making it a valuable compound in the development of medications for specific conditions.
Used in Anesthesia:
P-IODOCLONIDINE HYDROCHLORIDE is used as an adjunct in anesthesia for its potential to provide analgesia and sedation. Its action on the α2-adrenergic receptor can help in reducing the need for other anesthetic agents, thereby minimizing side effects and improving patient outcomes.
Used in Hypertension Treatment:
P-IODOCLONIDINE HYDROCHLORIDE is used as an antihypertensive agent due to its ability to cause vasodilation and lower blood pressure. Its interaction with the α2-adrenergic receptor can help in managing hypertension and reducing the risk of cardiovascular events.
Used in Ophthalmology:
P-IODOCLONIDINE HYDROCHLORIDE is used as a treatment for certain eye conditions, such as open-angle glaucoma. Its action on the α2-adrenergic receptor can help in reducing intraocular pressure, which is crucial in managing glaucoma and preventing vision loss.
Used in Neurology:
P-IODOCLONIDINE HYDROCHLORIDE is used as a neuromodulator for its potential to influence neuronal activity and transmission. Its interaction with the α2-adrenergic receptor can be beneficial in the treatment of various neurological disorders, such as attention deficit hyperactivity disorder (ADHD) and chronic pain conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 108294-53-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,2,9 and 4 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 108294-53:
(8*1)+(7*0)+(6*8)+(5*2)+(4*9)+(3*4)+(2*5)+(1*3)=127
127 % 10 = 7
So 108294-53-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H8Cl2IN3/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9/h3-4H,1-2H2,(H2,13,14,15)
108294-53-7Relevant articles and documents
Radioiodinated p-iodoclonidine: a high-affinity probe for the alpha 2-adrenergic receptor.
Van Dort,Neubig,Counsell
, p. 1241 - 1244 (2007/10/02)
The chemical synthesis of 2-[(2,6-dichloro-4-iodophenyl)imino]imidazolidine (PIC) and its radioiodinated analogue [125I]PIC is described. PIC was synthesized from 2,6-dichloroaniline in five synthetic steps. This agent displayed a high affinity for the alpha 2-adrenergic receptor (IC50 = 1.5 nM) in competitive binding assays conducted with purified human platelet plasma membrane fractions. For the synthesis of radioiodinated PIC the triazene intermediate 11 was synthesized from 2,6-dichloro-4-nitroaniline in five synthetic steps. Acid-catalyzed decomposition of 11 with no-carrier-added Na125I afforded high specific activity [125I]PIC. In view of its high affinity for the alpha 2-adrenergic receptor, [125I]PIC is a potentially useful probe for studies in adrenergic pharmacology.
