108555-00-6

Basic information

• Product Name: Sulfamic acid, 4-nitrophenyl ester
• CAS NO: 108555-00-6
• Molecular Formula: C6H6N2O5S
• Molecular Weight: 218.19
• Mol File: 108555-00-6.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Sulfamic acid, 4-nitrophenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Sulfamic acid, 4-nitrophenyl ester(108555-00-6)
• EPA Substance Registry System: Sulfamic acid, 4-nitrophenyl ester(108555-00-6)

Safety Data

• Hazardous Substances Data: 108555-00-6(Hazardous Substances Data)

Upstream product

• 100-02-7 4-nitro-phenol 
• 1400942-11-1 4-nitrophenyl 2-methyl-1H-imidazole-1-sulfonate 
• 1400942-31-5 4-nitrophenyl bis(2,4-dimethoxybenzyl)sulfamate 
• 73748-48-8 <(4-nitrophenyl)oxy>sulfonyl isocyanate 
• 99679-24-0 F-octyl-1 diisopropylamino-2 ethanol 
• 125672-20-0 F-hexyl-1 diisopropylamino-2 ethanol 
• 1189-71-5 isocyanate de chlorosulfonyle 

Downstream Products

• 100-02-7 4-nitro-phenol 
• 866490-18-8 cyclopentylsulfamide 
• 630412-68-9 1-fluoro-4-((4-nitrophenoxy)methyl)benzene 
• 25999-04-6 N-sulfamoylmorpholine 
• 4157-98-6 thiomorpholine-4-sulfonic acid amide 
• 5906-30-9 1-aminosulphonylpiperazine 

Relevant articles and documents

The action of F-alkylated (alkylamino)ethanols on alkoxy- and aroxy-sulfonyl isocyanates

The action of F-alkylated (alkylamino)ethanols on alkoxy- and aroxy-sulfonyl isocyanates allowed the preparation of the corresponding carbamates. The reaction occurred rapidly with good yields.

Pharmaceutical compositions (by machine translation)

[Problem] imidazole compound or its pharmacologically acceptable salt in the melanocortin receptor activity that operates as an active ingredient of a pharmaceutical composition comprising. "I" general formula [a]" Formula, the aryl group may be substituted A ring represents a; R1 Represents a hydrogen atom, or an alkyl group which may be substituted represented; R2 Represents a hydrogen atom, a halogen atom or represents a; R3 The alkyl group may be substituted " represented by the imidazole compound, its pharmacologically acceptable salt as an active ingredient in a pharmaceutical composition. [Drawing] no (by machine translation)

Elimination mechanisms in the aminolysis of sulfamate esters of the type NH2SO2OC6H2X - Models of enzyme inhibitors

The kinetics of the reaction of 4-nitrophenyl sulfamate NH 2SO2OC6H4NO2-4 (1a) in acetonitrile (ACN) with a series of pyridines (pKa range ca. 8 units) and alicyclic amines (pKa range ca. 3.6 units) has been studied in the presence of excess amine at various temperatures. The compounds 1a-1f are important as model substrates for the medicinally important sulfamate esters 667-coumate and emate and analogues. Pseudo-first-order rate constants (k obsd.) have been obtained mainly by the release of 4-nitrophenol/4-nitrophenoxide. Slopes of plots of kobsd. vs. [amine] gave second-order rate constants (k2), and Broensted plots were biphasic for the aminolysis (with alicyclic amines) with an initial slope β1 = 0.53 and a subsequent slope β2 = 0.19. The change in slope occurs near the first pKa of 1a (17.9) in ACN. Leaving-group effects were probed by using the same series of phenyl sulfamates, i.e. 1a-f and the alicyclic amines N-formylpiperazine and pyrrolidine. The reactions were considered to be dissociative in nature involving E2- and E1cB- type mechanisms with the phenyl sulfamate anion 2 being involved in pyridine and in the weaker alicyclic amines (β1 segment) and a phenyl sulfamate dianion 3 being involved with the stronger alicyclic bases (β2 segment). The calculation of Leffler indices (α) for bond-forming (base...H+) and bond-breaking (S-OAr) steps allows fuller interpretation of the mechanisms occurring, which are seen as having the N-sulfonylamines, HN=SO2 and -N=SO2 on the reaction pathways leading to products. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.