108773-31-5

Basic information

• Product Name: 2,2,2-trifluoro-N-(2-hydroxyphenethyl)acetamide
• Synonyms: 2,2,2-trifluoro-N-(2-hydroxyphenethyl)acetamide
• CAS NO: 108773-31-5
• Molecular Weight: 233.19
• Mol File: 108773-31-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,2,2-trifluoro-N-(2-hydroxyphenethyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trifluoro-N-(2-hydroxyphenethyl)acetamide(108773-31-5)
• EPA Substance Registry System: 2,2,2-trifluoro-N-(2-hydroxyphenethyl)acetamide(108773-31-5)

Safety Data

• Hazardous Substances Data: 108773-31-5(Hazardous Substances Data)

Upstream product

• 458-85-5 2,2,2-trifluoro-N-(2-phenylethyl)acetamide 
• 13062-80-1 2-(2-hydroxyphenyl)ethylamine hydrobromide 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 108773-06-4 S-<2-nitro-6-<2-(trifluoroacetamido)ethyl>phenyl>-N,N-dimethylthiocarbamate 
• 108795-57-9 O-<2-nitro-6-<2-(trifluoroacetamido)ethyl>phenyl>-N,N-dimethylthiocarbamate 
• 108773-07-5 S-<2-amino-6-<2-(trifluoroacetamido)ethyl>phenyl>-N,N-dimethylthiocarbamate 
• 108773-05-3 2-(2-hydroxy-3-nitrophenyl)-N-(trifluoroacetyl)ethylamine 

Relevant articles and documents

Computational and Experimental Studies of Phthaloyl Peroxide-Mediated Hydroxylation of Arenes Yield a More Reactive Derivative, 4,5-Dichlorophthaloyl Peroxide

The oxidation of arenes by the reagent phthaloyl peroxide provides a new method for the synthesis of phenols. A new, more reactive arene oxidizing reagent, 4,5-dichlorophthaloyl peroxide, computationally predicted and experimentally determined to possess enhanced reactivity, has expanded the scope of the reaction while maintaining a high level of tolerance for diverse functional groups. The reaction proceeds through a novel "reverse-rebound" mechanism with diradical intermediates. Mechanistic insight was achieved through isolation and characterization of minor byproducts, determination of linear free energy correlations, and computational analysis of substituent effects of arenes, each of which provided additional support for the reaction proceeding through the diradical pathway.