1089736-73-1

Basic information

• Product Name: L-Valine, N-(1-oxopentyl-d9)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-
• Synonyms: L-Valine, N-(1-oxopentyl-d9)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-;ACWBQPMHZXGDFX-KDDXQTGLSA-N
• CAS NO: 1089736-73-1
• Molecular Formula: C24H20D9N5O3
• Molecular Weight: 444.574216002
• Mol File: 1089736-73-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: L-Valine, N-(1-oxopentyl-d9)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Valine, N-(1-oxopentyl-d9)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-(1089736-73-1)
• EPA Substance Registry System: L-Valine, N-(1-oxopentyl-d9)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-(1089736-73-1)

Safety Data

• Hazardous Substances Data: 1089736-73-1(Hazardous Substances Data)

Usage

Description

L-Valine, N-(1-oxopentyl-d9)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]is a complex organic compound with a unique molecular structure. It is characterized by its isotopically labelled nature and is derived from Valsartan, a well-known nonpeptide angiotensin II AT1-receptor antagonist. L-Valine, N-(1-oxopentyl-d9)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]exhibits a white solid appearance and is primarily recognized for its potential applications in the pharmaceutical industry.

Uses

Used in Pharmaceutical Industry:
L-Valine, N-(1-oxopentyl-d9)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]is used as an isotopically labelled compound for the development and research of novel drugs and therapies. Its application reason lies in its ability to serve as a reference or tracer molecule in various pharmacological studies, allowing researchers to better understand the mechanisms of action, distribution, metabolism, and excretion of related drug candidates.
Used in Antihypertensive Applications:
As an isotopically labelled version of Valsartan, this compound is used as an antihypertensive agent. It functions by blocking the angiotensin II AT1-receptor, which plays a crucial role in regulating blood pressure. The application reason for its use in this context is to provide a more precise and controlled method for studying the effects of Valsartan on blood pressure regulation and to potentially develop more effective antihypertensive treatments.
Used in Drug Synthesis and Development:
L-Valine, N-(1-oxopentyl-d9)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]can also be used as a key intermediate or building block in the synthesis of new drugs and pharmaceutical compounds. Its application reason is based on its unique molecular structure, which may offer novel opportunities for the development of innovative therapeutic agents with improved efficacy, safety, and pharmacokinetic profiles.

Biological Activity

Valsartan-d9 is intended for use as an internal standard for the quantification of valsartan by GC- or LC-MS. Valsartan is a nonpeptide antagonist of the angiotensin II type 1 (AT1) receptor (IC50 = 2.7 nM). It is 20,000-fold selective for AT1 over AT2 and, unlike some other AT receptor antagonists, does not alter peroxisome proliferator-activated receptor γ (PPARγ) activity in vitro. In vivo, valsartan (30 mg/kg) increases cardiac output and reduces left ventricular fibrosis in a model of heart failure with reduced ejection fraction in mice with streptozotocin-induced diabetes. Formulations containing valsartan have been used in the treatment of hypertension and heart failure.