109564-82-1

Basic information

• Product Name: 5-phenethyloxy-resorcinol
• CAS NO: 109564-82-1
• Molecular Weight: 230.263
• Mol File: 109564-82-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-phenethyloxy-resorcinol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-phenethyloxy-resorcinol(109564-82-1)
• EPA Substance Registry System: 5-phenethyloxy-resorcinol(109564-82-1)

Safety Data

• Hazardous Substances Data: 109564-82-1(Hazardous Substances Data)

Upstream product

• 108-73-6 3,5-dihydroxyphenol 
• 60-12-8 2-phenylethanol 
• 103-63-9 1-phenyl-2-bromoethane 

Relevant articles and documents

SAR studies of acidic dual γ-secretase/PPARγ modulators

A novel set of dual γ-secretase/PPARγ modulators characterized by a 2-benzyl hexanoic acid scaffold is presented. Synthetic efforts were focused on the variation of the substitution pattern of the central benzene. Finally, we obtained a new class of 2,5-disubstituted 2-benzylidene hexanoic acid derivatives, which act as dual γ-secretase/PPARγ modulators in the low micromolar range. We have explored broad SAR and successfully improved the dual pharmacological activity and the selectivity profile against potential off-targets such as NOTCH and COX. Compound 17 showed an IC50 Aβ42 = 2.4 μM and an EC50 PPARγ = 7.2 μM and could be a valuable tool to further evaluate the concept of dual γ-secretase/ PPARγ modulators in animal models of Alzheimer's disease.