110915-67-8

Basic information

• Product Name: (E)-ethyl 2-fluoro-3-(3-cyanophenyl)acrylate
• Synonyms: (E)-ethyl 2-fluoro-3-(3-cyanophenyl)acrylate
• CAS NO: 110915-67-8
• Molecular Weight: 219.215
• Mol File: 110915-67-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-ethyl 2-fluoro-3-(3-cyanophenyl)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-ethyl 2-fluoro-3-(3-cyanophenyl)acrylate(110915-67-8)
• EPA Substance Registry System: (E)-ethyl 2-fluoro-3-(3-cyanophenyl)acrylate(110915-67-8)

Safety Data

• Hazardous Substances Data: 110915-67-8(Hazardous Substances Data)

Upstream product

• 401-55-8 ethyl bromofluoroacetate 
• 24964-64-5 3-Cyanobenzaldehyde 
• 1590374-22-3 (Z)-1-(3-cyanophenyl)-N-phenylmethanimine oxide 

Relevant articles and documents

Stereoselective synthesis of fluoroalkenoates and fluorinated isoxazolidinones: N-substituents governing the dual reactivity of nitrones

α-Fluoroalkenoates and 4-fluoro-5-isoxazolidinones are of vast interest due to their potential biological applications. We now demonstrate the syntheses of (E)-α-fluoroalkenoates and 4-fluoro-5-isoxazolidinones by the reactions between nitrones and α-fluoro-α-bromoacetate. By altering N-substituents in nitrones, (E)-α-fluoroalkenoates and 4-fluoro-5-isoxazolidinones can be achieved, respectively, with high chemo- and stereoselectivities. Experimental and computational studies have been conducted to elucidate the reaction mechanisms. Linear free energy relationship studies further revealed that the N-substituent effects are primarily of electronic origin. Copyright