1109226-33-6

Basic information

• Product Name: 2-propyl-5-(3-(trifluoromethyl)phenyl)thiazole
• Synonyms: 2-propyl-5-(3-(trifluoromethyl)phenyl)thiazole
• CAS NO: 1109226-33-6
• Molecular Weight: 271.306
• Mol File: 1109226-33-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-propyl-5-(3-(trifluoromethyl)phenyl)thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-propyl-5-(3-(trifluoromethyl)phenyl)thiazole(1109226-33-6)
• EPA Substance Registry System: 2-propyl-5-(3-(trifluoromethyl)phenyl)thiazole(1109226-33-6)

Safety Data

• Hazardous Substances Data: 1109226-33-6(Hazardous Substances Data)

Upstream product

• 17626-75-4 2-(n-propyl)-thiazole 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 

Relevant articles and documents

Solvent-free palladium-catalyzed direct arylation of heteroaromatics with aryl bromides

Solvent is one of the major sources of waste in the course of catalyzed direct arylations. Some palladium-catalyzed direct arylations of heteroaromatics can be advantageously performed without any solvent. In the presence of palladium catalysts (1 mol%) and potassium acetate as the base, the direct 5-arylation of some thiazoles, thiophenes, furans, or pyrroles with aryl bromides as coupling partners proceeds highly regioselectively and in moderate to high yields. However, the use of these solvent-free conditions is limited to electron-deficient aryl bromides. Copyright

Ligand-free palladium-catalyzed direct arylation of thiazoles at low catalyst loadings

Ligand-free Pd(OAc)2 was found to catalyze very efficiently the direct arylation of thiazole derivatives under very low catalyst concentration. By using activated aryl bromides, the reaction can be performed employing as little as 0.1-0.001 mol