111233-69-3Relevant articles and documents
Synthesis, structure and magnetic properties of oligometallic systems derived from di- and trinuclear copper(ii) amido-oximate complexes
Kolotilov, Sergey V.,Schollmeyer, Dieter,Thompson, Laurence K.,Golub, Vladimir,Addison, Anthony W.,Pavlishchuk, Vitaly V.
, p. 3007 - 3014 (2008)
Three heterometallic complexes [M(H2O)n][Cu 3L2(H2O)] (M = Mn2+, Co2+ or Ba2+) and one dinuclear compound (CuDien)(CuL{H2O}) were prepared by interaction of anionic compounds Cu3L 22- or CuL2- with the corresponding cations (H4L = 1,9-dicyano-1,9-bis(hydroximino)-3,7-diazanonane-2,8-dione; Dien = 1,5-diamino-3-azapentane). The complexes [M(H2O) n][Cu3L2(H2O)] have a polymeric structure, formed via oligomerization of Cu3L2 2- units and additionally, in the case of the Ba-salt, by binding of Cu3L22- units through Ba2+. Antiferromagnetic interactions occur in all the complexes, while for [Co(H 2O)6][Cu3L2(H2O)] there is evidence of some ferromagnetic ordering at low temperatures. The values of J are lower in magnitude than for similar, previously reported systems, which is attributed to the electron-withdrawing effect of the ligand cyano groups. The Royal Society of Chemistry 2008.
Parallel solution-phase synthesis of targeted tyrphostin libraries with anticancer activity
Hill, Timothy A.,Sakoff, Jennette A.,Robinson, Phillip J.,McCluskey, Adam
, p. 94 - 103 (2005)
The combination of semi-automation, an elegant synthesis, and parallel solution-phase synthesis approaches has allowed the development of five targeted, symmetrical tyrphostin compound libraries. These libraries on average are comprised of 12 compounds. Notwithstanding this, low micromolar potent growth inhibitors against HT29 (colorectal carcinoma) and G401 (renal carcinoma) cell lines were discovered. Additionally, significant SAR data was obtained. We noted that the most potent growth inhibitory activity was consistently observed for those analogues that possessed a 2-chlorophenyl (for 10: GI 50HT29 5.5 ± 0.4 μM, GI50G401 2.6 ± 0.4 μM; for 23: GI50HT29 2.4 ± 0.2 μM, GI50G401 1.9 ± 1 μM; for 34: GI50HT29 8.8 ± 3.1 μM. GI50G401 6.2 ± 2.9 μM; for 46: GI50HT29 5.2 ± 0.9 μM, GI50G401 3.7 ± 0.6 μM; for 57: GI 50HT29 4.6 ± 0.8 μM, GI50G401 2.1 ± 0.2 μM), a 3-chlorophenyl (for 11: GI50HT29 3.8 ± 0.7 μM, GI50G401 1.7 ± 0.7 μM; for 48: GI50HT29 5.9 ± 0.1 μM, GI50G401 3.4 ± 0.6 μM; for 58: GI 50HT29 4.8 ± 0.9 μM, GI50G401 3.4 ± 0.2 μM), or a 3-methoxyphenyl substituent (for 13: GI50HT29 7.4 ± 3.8 μM, GI50G401 2.8 ± 0.5 μM; for 26: GI 50HT29 4.5 ± 0.5 μM, GI50G401 4.9 ± 1 μM; for 37: GI50HT29 3.7 ± 0.2 μM, GI50G401 1.6 ± 0.2 μM; for 49: GI50HT29 3.7 ± 0.4 μM, GI50G401 3.4 ± 0.2 μM; for 60: GI50HT29 4.1 ± 0.6 μM, GI50G401 1.8 ± 0.3 μM). Finally, we noted that increasing the distance between the terminal aromatic rings had only a minimal effect on the 2-, 3-chlorophenyl, and 3-methoxyphenyl analogues, but did have a favourable effect on OH, COOH, and multiply substituted analogues. CSIRO 2005.
Effective synthesis of new benzo-fused macrocyclic and thiamacrocyclic dilactams and related pyrazolo-fused macrocycles
Ahmed, Ahmed A. M.,Mekky, Ahmed E. M.,Sanad, Sherif M. H.
, p. 286 - 296 (2021/10/19)
In the current study, we examined the synthetic potential of new bis(aldehydes), linked to aliphatic spacers via phenoxy linkage, as versatile building blocks for the synthesis of new macrocyclic dilactams. The target macrocycles were prepared, in 65%–72%
Design and synthesis of 2-pyridone based flexible dimers and their conformational study through X-ray diffraction and density functional theory: Perspective of cyclooxygenase-2 inhibition
Rai, Sunil K.,Khanam, Shaziya,Khanna, Ranjana S.,Tewari, Ashish K.
, p. 1430 - 1439 (2015/05/20)
This paper describes the results of X-ray crystallography of 4-methyl-2-oxo-6-phenyl-1,2-dihydropyridine-3-carbonitrile (1) and its propylene bridged dimers 2 and 3. Influence of inter- and intramolecular interactions on the conformation of propylene link
Efficient synthesis of new butenolides by subsequent reactions: Application for the synthesis of original iminolactones, bis-iminolactones and bis-lactones
Cheikh, Nawel,Bar, Nathalie,Choukchou-Braham, Nourredine,Mostefa-Kara, Bachir,Lohier, Jean-Franois,Sopkova, Jana,Villemin, Didier
experimental part, p. 1540 - 1551 (2011/04/15)
We have developed the synthesis of twenty four new iminolactones, bis-iminolactones and bis-lactones by subsequent esterification-condensation or addition-condensation reactions according to two strategies from α-hydroxyketones. The X-ray diffraction data of a bis-iminolactone is described and present an interesting helical column packing.
