112014-72-9

Basic information

• Product Name: benzyl 4-benzyloxy-3-carbamoyl-5-methoxy-1,2,3,6-tetrahydropyrrolo<3,2-e>indole-7-carboxylate
• CAS NO: 112014-72-9
• Molecular Weight: 471.513
• Mol File: 112014-72-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: benzyl 4-benzyloxy-3-carbamoyl-5-methoxy-1,2,3,6-tetrahydropyrrolo<3,2-e>indole-7-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 4-benzyloxy-3-carbamoyl-5-methoxy-1,2,3,6-tetrahydropyrrolo<3,2-e>indole-7-carboxylate(112014-72-9)
• EPA Substance Registry System: benzyl 4-benzyloxy-3-carbamoyl-5-methoxy-1,2,3,6-tetrahydropyrrolo<3,2-e>indole-7-carboxylate(112014-72-9)

Safety Data

• Hazardous Substances Data: 112014-72-9(Hazardous Substances Data)

Upstream product

• 1118-02-1 trimethylsilyl isocyanate 
• 102357-94-8 benzyl 4-benzyloxy-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate 
• 112014-71-8 benzyl 4-benzyloxy-3,6-dihydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate 

Downstream Products

• 62497-62-5 6-aminocarbonyl-3,6,7,8-tetrahydro-5-hydroxy-4-methoxybenzo[1,2-b:4,3-b']dipyrrole-2-carboxylic acid 

Relevant articles and documents

Vinyl Azides in Heterocyclic Synthesis. Part 8. Synthesis of the Naturally Occuring Phosphodiesterase Inhibitors PDE-I and PDE-II

The synthesis of the naturally occuring pyrroloindole phosphodiesterase inhibitors PDE-I (1) and PDE-II (2) from isovanillin is described.The route involves the construction of both pyrrole rings by vinylnitrene cyclisations, the key cyclisation substrates being the azidoacrylates (5) and (11), prepared from the aldehydes (4) and (10) respectively.The tricyclic intermediate (12) is converted into both PDE-I and PDE-II by selective reduction, followed by carbamoylation or acetylation respectively, and deprotection.