112088-88-7

Basic information

• Product Name: 9H-Purine, 6-chloro-9-[(3-fluorophenyl)methyl]-
• CAS NO: 112088-88-7
• Molecular Formula: C12H8ClFN4
• Molecular Weight: 262.674
• Mol File: 112088-88-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 9H-Purine, 6-chloro-9-[(3-fluorophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-Purine, 6-chloro-9-[(3-fluorophenyl)methyl]-(112088-88-7)
• EPA Substance Registry System: 9H-Purine, 6-chloro-9-[(3-fluorophenyl)methyl]-(112088-88-7)

Safety Data

• Hazardous Substances Data: 112088-88-7(Hazardous Substances Data)

Upstream product

• 87-42-3 6-chloropurine 
• 456-42-8 m-fluorobenzyl chloride 
• 100-82-3 (3-fluorophenyl)methanamine 
• 122-51-0 orthoformic acid triethyl ester 
• 112088-66-1 5-amino-4-chloro-6-<(3-fluorobenzyl)amino>pyrimidine 

Relevant articles and documents

Synthesis and anticonvulsant activity of novel purine derivatives

A series of new purines containing triazole and other heterocycle substituents was synthesized and evaluated for their preliminary anticonvulsant activity and neurotoxicity by using the maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ) and rotarod neurotoxicity (TOX) tests. Among the compounds studied, 9-decyl-6-(1H-1,2,4-triazol-1-yl)-9H-purine (5e) was the most potent compound, with a median effective dose of 23.4 mg/kg and a high protective index of more than 25.6 after intraperitoneal administration in mice. Compound 5e showed significant oral activity against MESinduced seizures in mice, with an ED50 of 39.4 mg/kg and a PI above 31.6. These results demonstrate that compound 5e possesses better anticonvulsant activity and is safer than the commercially available drugs carbamazepine and valproate in MES, scPTZ and TOX models.

6-(Alkylamino)-9-benzyl-9H-purines. A New Class of Anticonvulsant Agents

Several 9-alkyl-6-substituted-purines were synthesized and tested for anticonvulsant activity against maximal electroshock-induced seizures (MES) in rats.Most compounds were prepared in three steps from 5-amino-4,6-dichloropyrimidine or in two steps via alkylation of 6-chloropurine.Potent anticonvulsant activity against MES resided in compounds that contain a benzyl substituent at the 9-position of 6-(methylamino)- or 6-(dimethylamino)purine.Among commonly used agents for control of seizures, this type of structure represents a new class of potent anticonvulsant agents.