112193-35-8 Usage
Description
N-(5-hydroxynicotinoyl)-L-glutamic acid, also known as nooglutil, is an organic compound that serves as an intermediate in both organic synthesis and pharmaceutical development. It is primarily utilized in laboratory research and development processes, as well as in chemical production.
Usage:
Used in Pharmaceutical Industry:
Nooglutil is used as a pharmaceutical intermediate for the development of various medications. Its unique chemical structure allows it to be a key component in the synthesis of drugs targeting specific health conditions.
Used in Organic Synthesis:
In the field of organic synthesis, nooglutil is used as an intermediate to create a range of chemical compounds. Its versatility in chemical reactions makes it valuable for developing new organic molecules with potential applications in various industries.
Used in Research and Development:
Nooglutil plays a crucial role in laboratory research and development processes. It aids scientists in understanding the fundamental properties of related compounds and contributes to the advancement of chemical knowledge and innovation.
Used in Chemical Production Process:
In the chemical production industry, nooglutil is utilized in the manufacturing process of various chemical products. Its presence in the synthesis chain ensures the production of high-quality end products that meet industry standards.
Synthesis
A solution of 233 g (5.83 mol) of NaOH in 930 mL of water was added to 345 g of the raw diethyl ester 15 ina 3-L one-neck flask, and the mixture was stirred a troom temperature for 2 h, after which 30 g of activated carbon was added, and stirring was continued for an additional 30 min and filtered on a Buchner funnel tor remove the activated carbon. The filtrate was made acidic (pH 4) by adding 545 mL of conc. HCl and stirred for 1 h. The precipitate was filtered off (Schott filter no. 3), washed with water (3 × 600 mL), suspended in 750 mL of water, acidified to pH 4 with 65 mL of conc. HCl, and immediately neutralized to pH 8 with 90 mL of 40% NaOH. Activated carbon, 13 g, was then added, and the mixture was stirred for 30 min, the activated carbon was removed by filtration, and the filtrate was acidified to pH 4 with conc. HCl. The precipitate was filtered off, washed with water (3 × 500 mL), and dried at 55 °C and a vacuum of 40 mmHg for 12 h to obtain 129 g (70%) of the target product, purity by HPLC 99.61%, main substance content by titration 80% (water 21%).
Check Digit Verification of cas no
The CAS Registry Mumber 112193-35-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,1,9 and 3 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 112193-35:
(8*1)+(7*1)+(6*2)+(5*1)+(4*9)+(3*3)+(2*3)+(1*5)=88
88 % 10 = 8
So 112193-35-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H12N2O6/c14-7-3-6(4-12-5-7)10(17)13-8(11(18)19)1-2-9(15)16/h3-5,8,14H,1-2H2,(H,13,17)(H,15,16)(H,18,19)/t8-/m0/s1
112193-35-8Relevant articles and documents
A New Synthesis of Calcium N-(5-Hydroxynicotinoyl)-L-glutamate and Its X-ray Diffraction Structure
Kiselev,Machula,Efimov,Pashkova,Stovbun
, p. 615 - 619 (2019/07/17)
A new synthesis of N-(5-hydroxynicotinoyl)-L-glutamic acid via a 5-hydroxynicotinic acid imidazolide intermediate has been developed. Its calcium salt (Ampasse) has been synthesized and its structure was studied by X-ray diffraction analysis. The reaction conditions for all stages of the process have been optimized and a method for the purification of the substance has been improved.
