1122-47-0Relevant articles and documents
Permanganate oxidation of 4-thiouracil derivatives. Isolation and properties of 1-substituted-2-pyrimidone-4-sulfonates.
Hayatsu,Yano
, p. 755 - 758 (1969)
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One-Electron Redox Potentials of Purines and Pyrimidines
Jovanovic, Slobodan V.,Simic, Michael G.
, p. 974 - 978 (1986)
One-electron redox potentials of some purine and pyrimidine derivatives were determined by pulse radiolysis from electron transfer equilibria involving their and other free radicals.The redox potentials were determined at pH 13 by using p-methoxyphenol (E=0.4 V), Trolox C (E=0.19 V), and tryptophan (E=0.56 V) as references.The lowest oxidation potential measured for DNA bases was guanosine (E=0.72 V vs.NHE), and the highest was for 1-methylpyrimidines (E ca. 1.6 V) Uric acid (E=0.26 V) and isobarbituric acid (E=0.13 V) were found to have the lowest potentials.
Permanganate oxidation of 4-thiouracil derivatives. Isolation and properties of I-substituted 2-pyrimidone 4-sulfonates.
Yano,Hayatsu
, p. 303 - 315 (1970)
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Yamauchi et al.
, p. 3691,3692, 3695 (1976)
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Cytosine modules in quadruple hydrogen bonded arrays
Greco, Elisabetta,Aliev, Abil E.,Lafitte, Valerie G. H.,Bala, Kason,Duncan, David,Pilon, Laura,Golding, Peter,Hailes, Helen C.
, p. 2634 - 2642 (2010)
Cytosine modules have been investigated for applications in supramolecular quadruple hydrogen bonded arrays. Notably, the importance of the C-5-H in the formation of unfolded and folded arrays by substitution to C-5-F was established. In addition, the incorporation of different alkyl chain lengths at N-1 and N-9 indicated that longer alkyl chains give rise to more of the unfolded rotamer, with the chain length and degree of unsaturation at N-1 having the major effect. Methyl cytosine modules were also able to readily form hetero-associated Upy-UCyt dimers as efficiently as the hexyl cytosine modules and a polyadipate telechelic polymer was used to prepare cytosine polymers.
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Brookes,Lawley
, p. 1348,1350 (1962)
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SUBSTITUTED IMADAZAPYRINIDIN-5(6H)-ONES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS
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Page/Page column 191-192, (2012/10/07)
In one aspect, the invention relates to imidazopyrimidin-5(6H)-one analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Synthesis of modified pyrimidine bases and positive impact of chemically reactive substituents on their in vitro antiproliferative activity
Noll, Steffi,Kralj, Marijeta,Suman, Lidija,Stephan, Holger,Piantanida, Ivo
body text, p. 1172 - 1179 (2009/09/30)
The antiproliferative activity screening on human tumor cell lines of a series of modified uracil and cytosine bases as well as some corresponding acyclonucleosides, and comparison of structure-activity relationship revealed the importance of chemical rea