1122047-98-6Relevant articles and documents
Cytochromes P450 catalyze both steps of the major pathway of clopidogrel bioactivation, whereas paraoxonase catalyzes the formation of a minor thiol metabolite isomer
Dansette, Patrick M.,Rosi, Julien,Bertho, Gildas,Mansuy, Daniel
, p. 348 - 356 (2012)
The mechanism generally admitted for the bioactivation of the antithrombotic prodrug, clopidogrel, is its two-step enzymatic conversion into a biologically active thiol metabolite. The first step is a classical cytochrome P450 (P450)-dependent monooxygena