112260-69-2

Basic information

• Product Name: Ethanone, 2-fluoro-1-(1-naphthalenyl)- (9CI)
• Synonyms: Ethanone, 2-fluoro-1-(1-naphthalenyl)- (9CI)
• CAS NO: 112260-69-2
• Molecular Formula: C₁₂H₉FO
• Molecular Weight: 188.1976632
• Product Categories: ACETYLHALIDE
• Mol File: 112260-69-2.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 2-fluoro-1-(1-naphthalenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-fluoro-1-(1-naphthalenyl)- (9CI)(112260-69-2)
• EPA Substance Registry System: Ethanone, 2-fluoro-1-(1-naphthalenyl)- (9CI)(112260-69-2)

Safety Data

• Hazardous Substances Data: 112260-69-2(Hazardous Substances Data)

Upstream product

• 91-20-3 naphthalene 
• 941-98-0 1'-naphthacetophenone 
• 67-56-1 methanol 
• 76103-97-4 3-(naphthalene-1-yl)-3-oxopropanoic acid 
• 91077-76-8 α-Trimethylsilyloxy-α-(1-naphthyl)ethylene 
• 413598-04-6 (2,2-difluoro-1-naphthalen-1-yl-vinyloxy)-trimethyl-silane 
• 6500-37-4 2,2,2-trifluoro-1-(naphthalen-1-yl)ethanone 
• 715-80-0 2,2-difluoro-1-(naphthalen-1-yl)ethan-1-one 
• 413598-39-7 ((E)-2-Fluoro-1-naphthalen-1-yl-vinyloxy)-trimethyl-silane 

Downstream Products

• 64977-43-1 2-fluoro-1-(naphthalen-1-yl)-2-phenylethan-1-one 
• 1325147-00-9 (S)-2-fluoro-1-(naphthalen-1-yl)ethyl benzoate 
• 941-98-0 1'-naphthacetophenone 
• 112260-71-6 1-(1,1-Bis-ethylsulfanyl-ethyl)-naphthalene 

Relevant articles and documents

Hypervalent iodine-promoted α-fluorination of acetophenone derivatives with a triethylamine·hf complex

The direct fluorination reaction of acetophenone using iodosylarenes and TEA·5HF was conducted under mild conditions except for use of a HF reagent. The fluorination reaction was applied to acetophenone derivatives, acetonaphthones, benzyl phenyl ketone, propiophenone, butyrophenone, 1-indanone, and phenacyl chloride, giving selectively the corresponding α-fluoroketone derivatives in good yields.

Α - fluoro acetophenone derivative

PROBLEM TO BE SOLVED: To provide a new production method of an α-fluoroacetophenone derivative by a simple one-step fluorination reaction with an acetophenone derivative under a mild condition.SOLUTION: An acetophenone derivative represented by formula (I) is reacted with a hydrogen fluoride/amine complex in the presence of a hypervalent iodine compound, (in the formula, a ring A indicates an aromatic ring of 1-3 members; Rindicates a hydrogen atom or an aromatic ring of 1-3 members that may be substituted; Rindicates a hydrogen atom or an alkyl group of 1-6 carbons; and Rindicates a hydrogen atom, an alkyl group of 1-6 carbons, an alkoxy group of 1-6 carbons or a halogen atom). The H part in formula (I) is substituted and fluorinated.

A Practical Synthesis of α-Fluoroketones in Aqueous Media by Decarboxylative Fluorination of β-Ketoacids

A practical and novel process for the decarboxylative fluorination of β-ketoacids in water in the presence of phase transfer catalyst has been developed, affording a series of α-fluoroketones in good to excellent yields. Furthermore, a preliminary investigation for the catalytic asymmetric transformation was performed and a proposed mechanistic pathway for this catalytic process was proposed.