1123645-77-1Relevant articles and documents
Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase
Cee, Victor J.,Cheng, Alan C.,Romero, Karina,Bellon, Steve,Mohr, Christopher,Whittington, Douglas A.,Bak, Annette,Bready, James,Caenepeel, Sean,Coxon, Angela,Deak, Holly L.,Fretland, Jenne,Gu, Yan,Hodous, Brian L.,Huang, Xin,Kim, Joseph L.,Lin, Jasmine,Long, Alexander M.,Nguyen, Hanh,Olivieri, Philip R.,Patel, Vinod F.,Wang, Ling,Zhou, Yihong,Hughes, Paul,Geuns-Meyer, Stephanie
, p. 424 - 427 (2009)
Selective small molecule inhibitors of Tie-2 kinase are important tools for the validation of Tie-2 signaling in pathological angiogenesis. Reported herein is the optimization of a nonselective scaffold into a potent and highly selective inhibitor of Tie-2 kinase.
