112448-69-8

Basic information

• Product Name: 3-Phenyl-1-(pyrrol-1-yl)propan-1-one
• Synonyms: 3-Phenyl-1-(pyrrol-1-yl)propan-1-one;1-(1-Oxo-3-phenylpropyl)-1H-pyrrole
• CAS NO: 112448-69-8
• Molecular Formula: C₁₃H₁₃NO
• Molecular Weight: 199.24842
• Mol File: 112448-69-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 46-48℃
• Appearance: /
• CAS DataBase Reference: 3-Phenyl-1-(pyrrol-1-yl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Phenyl-1-(pyrrol-1-yl)propan-1-one(112448-69-8)
• EPA Substance Registry System: 3-Phenyl-1-(pyrrol-1-yl)propan-1-one(112448-69-8)

Safety Data

• Hazardous Substances Data: 112448-69-8(Hazardous Substances Data)

Usage

General Description

3-Phenyl-1-(pyrrol-1-yl)propan-1-one, also known as P3P, is a chemical compound with the molecular formula C13H13NO. It is a ketone compound with a phenyl group and a pyrrol-1-yl group attached to a propanone backbone. P3P is often used as a precursor in the synthesis of various pharmaceuticals and research chemicals, and is also commonly used as a reagent in organic chemistry reactions. It is known for its mild stimulant effects when ingested or inhaled, and has also been studied for its potential therapeutic applications in neurodegenerative diseases. However, P3P is not approved for human consumption or medical use, and it should be handled with caution due to its potential health and safety hazards.

Upstream product

• 20671-52-7 lithium pyrrolide 
• 645-45-4 hydrocinnamic acid chloride 
• 109-97-7 pyrrole 
• 501-52-0 3-Phenylpropionic acid 
• 55628-83-6 1-(1H-imidazol-1-yl)-3-phenylpropan-1-one 
• 173549-40-1 1-(3-phenylpropanoyl)-2,5-dihydropyrrole 

Downstream Products

• 19969-04-1 1-phenyl-heptan-3-one 
• 91119-04-9 5-(2-phenylethyl)-5-nonanol 
• 173549-44-5 1-phenyl-3-(1-pyrrolyl)-3-heptanol 
• 103-25-3 3-phenylpropanoic acid methyl ester 
• 850662-61-2 1-(3-phenylpropyl)-1H-pyrrole 
• 497147-46-3 1-(1,3-diphenyl-1-trimethylsilanyloxy-propyl)-1H-pyrrole 
• 1083-30-3 dihydrochalcone 
• 19332-07-1 2,4-diphenyl-butan-2-ol 

Relevant articles and documents

Structural elucidation and synthesis of new components isolated frompipersarmentosum(piperaceae)

Six components were Isolated from the fruit ofPipersarmentosum. Two of the components are the ubiquitous β-sitosterol and the known unsaturated amide, pellitorine, 3. The other four components, which are new natural products, consist of the aromatic alken

Remarkably stable tetrahedral intermediates: Carbinols from nucleophilic additions to N-acylpyrroles

Sufficiently stable intermediates formed in the reaction of N-acylpyrroles (1) with hydride and Grignard reagents can undergo further synthetic transformations and chromatographic purification to enable the generation of pyrrolecarbinols 2 in 76-95% yields [Eq. (1)].

On the Preparation of N-Acylpyrroles and their Use in the Synthesis of Ketones

Two methods for the preparation of N-acylpyrroles have been studied: (a) the reaction between pyrrole and N-acylimidazoles and (b) the oxidation of amides of 3-pyrroline.The reactions between N-acylpyrroles and organolithium compounds can be directed to give ketones in good yields.The initially formed tetrahedral intermediates in these reactions are relatively stable and pyrrolylcarbinols are isolable intermediates.A Reformatsky-Claisen type ring-closure gave a more than doubled yield when an N-acylpyrrole group was used as an electrophile instead of an ester group; the increased stability of the initially formed tetrahedral intermediate presumably accounts for the observed results.