1127405-04-2Relevant articles and documents
Solvent-free one-pot oxidation of ethylarenes for the preparation of α-ketoamides under mild conditions
Liu, Fuyan,Zhang, Kuan,Liu, Yanfeng,Chen, Shan,Chen, Yiping,Zhang, Dela,Lin, Chunfu,Wang, Bo
, p. 7158 - 7162 (2017/02/05)
Here we developed a highly efficient solvent-free, one-pot procedure for synthesizing α-ketoamides from ethylarenes and amines, by oxidizing a C-H bond sp3 center. A copper catalyst was employed, and the reactions proceeded smoothly at ambient temperatures. Most of the tested ethylarenes and amines were successfully converted to their corresponding α-ketoamides in moderate to excellent yields of up to 93% with three equivalents of the oxidant tert-butyl hydroperoxide.
A general and efficient copper catalyst for the double carbonylation reaction
Liu, Jianming,Zhang, Rongzhao,Wang, Shoufeng,Sun, Wei,Xia, Chungu
supporting information; experimental part, p. 1321 - 1324 (2009/09/24)
The use of (NHC)Cul complex in combination with a N-heterocyclic carbene precursor as catalyst for the double carbonylation of aryl Iodides and secondary amines solves the problem of using the precious metal Pd and phosphine ligands. The new protocol requ