1144516-21-1

Basic information

• Product Name: Neratinib
• Synonyms: Neratinib Impurity 5
• CAS NO: 1144516-21-1
• Molecular Formula: C29H27ClN6O2
• Molecular Weight: 527.02
• Mol File: 1144516-21-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 709.0±70.0 °C(Predicted)
• Appearance: /
• Density: 1.30±0.1 g/cm3(Predicted)
• PKA: 8.80±0.20(Predicted)
• CAS DataBase Reference: Neratinib(CAS DataBase Reference)
• NIST Chemistry Reference: Neratinib(1144516-21-1)
• EPA Substance Registry System: Neratinib(1144516-21-1)

Safety Data

• Hazardous Substances Data: 1144516-21-1(Hazardous Substances Data)

Usage

General Description

Neratinib is a potent, irreversible tyrosine kinase inhibitor that has shown significant activity against several types of cancer, including breast and lung cancer. It works by inhibiting the HER2 and EGFR receptors, which are overexpressed in many cancer cells, leading to unchecked cell growth and proliferation. Neratinib has been approved for the treatment of certain types of metastatic breast cancer, and ongoing research is investigating its potential in treating other types of cancer. However, it is also associated with a range of side effects, including diarrhea, nausea, vomiting, and liver toxicity, which can limit its use in some patients. Overall, neratinib represents a promising targeted therapy for certain types of cancer, but its side effects and limited efficacy in some patients are important considerations in its use.