1147998-34-2

Basic information

• Product Name: benzyl 4-(triMethylsilylo×y)-5,6-dihydropyridine-1(2H)-carbo×ylate
• Synonyms: benzyl 4-(triMethylsilylo×y)-5,6-dihydropyridine-1(2H)-carbo×ylate;Benzyl 4-((triMethylsilyl)oxy)-5,6-dihydropyridine-1(2H)-carboxylate
• CAS NO: 1147998-34-2
• Molecular Formula: C₁₆H₂₃NO₃Si
• Molecular Weight: 305.44422
• Mol File: 1147998-34-2.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: benzyl 4-(triMethylsilylo×y)-5,6-dihydropyridine-1(2H)-carbo×ylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 4-(triMethylsilylo×y)-5,6-dihydropyridine-1(2H)-carbo×ylate(1147998-34-2)
• EPA Substance Registry System: benzyl 4-(triMethylsilylo×y)-5,6-dihydropyridine-1(2H)-carbo×ylate(1147998-34-2)

Safety Data

• Hazardous Substances Data: 1147998-34-2(Hazardous Substances Data)

Usage

Description

Benzyl 4-(trimethylsilyloxy)-5,6-dihydropyridine-1(2H)-carboxylate is a chemical compound derived from pyridine, featuring a trimethylsilyloxy group that acts as a protecting agent for the carboxylate functionality. This unique structure and reactivity make it a valuable building block in organic synthesis, particularly for the development of pharmaceuticals and agrochemicals.

Uses

Used in Pharmaceutical and Agrochemical Industries:
Benzyl 4-(trimethylsilyloxy)-5,6-dihydropyridine-1(2H)-carboxylate is utilized as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its protective trimethylsilyloxy group allows for selective manipulation of the molecule during synthetic procedures, facilitating the creation of complex organic molecules with potential therapeutic or pesticidal properties.
Used in Medicinal Chemistry and Drug Development:
In the field of medicinal chemistry, benzyl 4-(trimethylsilyloxy)-5,6-dihydropyridine-1(2H)-carboxylate serves as a key component in the design and synthesis of new drug candidates. Its unique structure contributes to the development of molecules with specific biological activities, making it an important tool in drug discovery and optimization processes.
Used in the Production of Fine Chemicals:
Benzyl 4-(trimethylsilyloxy)-5,6-dihydropyridine-1(2H)-carboxylate is also employed in the manufacture of fine chemicals, which are high-purity chemical compounds used in various applications, including research, diagnostics, and the production of specialty products. Its role in these processes highlights its versatility and importance in the chemical industry.

Upstream product

• 6099-86-1 cyclohexylmethyl chlorocarbonate 
• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 913574-95-5 benzyl cis-3-fluoro-4-hydroxypiperidine-1-carboxylate 
• 955029-44-4 (syn)-3-fluoro-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester 
• 847041-34-3 benzyl (3R,4S)-4-[{[(2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl]carbonyl}(methyl)amino]-3-fluoropiperidine-1-carboxylate 
• 845256-80-6 C₁₄H₁₉FN₂O₂ 
• 845256-61-3 benzyl (3R,4S)-4-[(tert-butoxycarbonyl)(methyl)amino]-3-fluoropiperidine-1-carboxylate 
• 847041-33-2 benzyl (3S,4R)-4-[(tert-butoxycarbonyl)(methyl)amino]-3-fluoropiperidine-1-carboxylate 
• 845256-78-2 (2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoropiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide 
• 913574-95-5 benzyl cis-3-fluoro-4-hydroxypiperidine-1-carboxylate 
• 1209780-78-8 benzyl (3S,4S)-3-fluoro-4-((4-nitrobenzoyl)oxy)piperidine-1-carboxylate 

Relevant articles and documents

Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists

G protein-coupled receptor 40 (GPR40) has become an attractive target for the treatment of diabetes since it was shown clinically to promote glucose-stimulated insulin secretion. Herein, we report our efforts to develop highly selective and potent GPR40 agonists with a dual mechanism of action, promoting both glucose-dependent insulin and incretin secretion. Employing strategies to increase polarity and the ratio of sp3/sp2 character of the chemotype, we identified BMS-986118 (compound 4), which showed potent and selective GPR40 agonist activity in vitro. In vivo, compound 4 demonstrated insulinotropic efficacy and GLP-1 secretory effects resulting in improved glucose control in acute animal models.

Dihydropyrazole GPR40 modulators

The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

FATTY ACID SYNTHASE INHIBITORS

This invention relates to novel spirocyclic piperidines according to Formula (I) which are inhibitors of fatty acid synthase (FAS), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.