1148040-91-8

Basic information

• Product Name: ethyl 5-[(diethylamino)methylene]-2-(p-methoxybenzyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate
• Synonyms: ethyl 5-[(diethylamino)methylene]-2-(p-methoxybenzyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate
• CAS NO: 1148040-91-8
• Molecular Weight: 396.486
• Mol File: 1148040-91-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 5-[(diethylamino)methylene]-2-(p-methoxybenzyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-[(diethylamino)methylene]-2-(p-methoxybenzyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate(1148040-91-8)
• EPA Substance Registry System: ethyl 5-[(diethylamino)methylene]-2-(p-methoxybenzyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate(1148040-91-8)

Safety Data

• Hazardous Substances Data: 1148040-91-8(Hazardous Substances Data)

Upstream product

• 5815-08-7 tert-Butoxybis(dimethylamino)methane 
• 1148040-86-1 ethyl 2-(p-methoxybenzyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate 
• 918-02-5 N,N-dimethyl-tert-butylamine 

Downstream Products

• 1148041-00-2 7-ethyl 3-methyl 8-(p-methoxylbenzyl)-9-methyl-2-oxo-2,5,6,8-tetrahydropyrano[2,3-e]isoindole-3,7-dicarboxylate 
• 1148040-97-4 diethyl 8-(p-methoxybenzyl)-9-methyl-2-oxo-2,5,6,8-tetrahydropyrano[2,3-e]isoindole-3,7-dicarboxylate 
• 1575821-90-7 ethyl 8-(4-methoxybenzyl)-9-methyl-2-(phenylamino)-6,8-dihydro-5H-pyrrolo[3,4-h]quinazoline-7-carboxylate 
• 1575821-76-9 ethyl 2-amino-8-(4-methoxybenzyl)-9-methyl-6,8-dihydro-5H-pyrrolo[3,4-h]quinazoline-7-carboxylate 

Relevant articles and documents

Synthesis of a new class of pyrrolo[3,4-h]quinazolines with antimitotic activity

A new series of pyrrolo[3,4-h]quinazolines was conveniently prepared with a broad substitution pattern. A large number of derivatives was obtained and the cellular cytotoxicity was evaluated in vitro against 5 different human tumor cell lines with GI50 values reaching the low micromolar level (1.3-19.8 μM). These compounds were able to induce cell death mainly by apoptosis through a mitochondrial dependent pathway. Selected compounds showed antimitotic activity and a reduction of tubulin polymerization in a concentration-dependent manner. Moreover, they showed anti-angiogenic properties since reduced in vitro endothelial cell migration and disrupted HUVEC capillary-like tube network in Matrigel.